This review focuses on the polycaprolactone (PCL)-based meniscus biomaterials involved in meniscal repair and regeneration. Poly-ε-caprolactone (PCL) is a well-known polymer that has attracted enormous attention from both the research community and industry due to its biocompatibility, structural stability, and capacity to form blends with many other polymers. The progress made in meniscal tissue engineering and PCL-based biomaterials allowed several meniscal substitutes with extracellular matrix materials (ECM), natural materials, synthetic or hybrids. The present manuscript aims to review the scientific evidence to understand the current state of research in this particular field and to identify the trends at the PCL-based meniscal scaffolds. The literature search of the PubMed, Scopus, ACM Digital Library and Medline databases was undertaken to identify all studies that reported PCL based meniscal scaffold regeneration. Twenty nine were included in the present analysis 20 cases of meniscal scaffolds were used with cells to stimulate tissue regeneration further. The majority of the trials showed that PCL-based hybrid biocomposites and bio-engineered scaffolds on enhancing cell attachment and proliferation, conferring chondroprotective properties. Finally, we review the latest and promising advances associated, bioprinted and electrospun meniscal implants and the drive toward more functional boinks, hybrid, and natural biocomposites with the overall goal of achieving a patient-specific meniscal implant.

Original languageEnglish
Title of host publication1st International Conference on Neuroscience and Learning Technology, ICONSATIN 2021
EditorsArika Indah Kristiana, Ridho Alfarisi
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735443006
Publication statusPublished - 4 Jan 2023
Event1st International Conference on Neuroscience and Learning Technology, ICONSATIN 2021 - Jember, Indonesia
Duration: 18 Sept 202119 Sept 2021

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Conference1st International Conference on Neuroscience and Learning Technology, ICONSATIN 2021


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