TY - JOUR
T1 - Plant description, phytochemical constituents and bioactivities of Syzygium genus
T2 - A review
AU - Aung, Ei Ei
AU - Kristanti, Alfinda Novi
AU - Aminah, Nanik Siti
AU - Takaya, Yoshiaki
AU - Ramadhan, Rico
N1 - Publisher Copyright:
© 2020 Ei Ei Aung et al.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - This article attempts to report native growth, plant description, phytochemical constituents and bioactivities of Syzygium aqueum, S. aromaticum, S. cumini, S. guineense and S. samarangense. Those are the large public species in the Syzygium genus and some of them have been used as traditional medicines. Different parts (leaves, seeds, fruits, barks, stem barks and flower buds) of each species plant are rich in phytochemical constituents such as flavonoids, terpenoids, tannins, glycosides and phenolics. Antioxidant, antidiabetic, anticancer, toxicity, antimicrobial, anti-inflammatory and anthelmintic activities are reported in various extracts (methanol, ethanol and aqueous) from different parts of Syzygium sp. The bioactivities were studied by using 1,1-diphenyl-2-picrylhydrazyl and ferric reducing antioxidant power assays for antioxidant, 5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazoly)- 3-(4-sulfophenyl) tetrazolium and 3-(4,5-dimethylthiazol- 2-yl)-2-5-diphenyltetrazolium bromide assays for anticancer, α-glucosidase and α-amylase inhibition assays for antidiabetic, agar well diffusion method for antimicrobial and brine shrimp lethality assay for toxicity. Moreover, this review shows that phytochemical constituents of each species significantly presented various bioactivities. Therefore, this review suggests that there is great potential for obtaining the lead drug from these species.
AB - This article attempts to report native growth, plant description, phytochemical constituents and bioactivities of Syzygium aqueum, S. aromaticum, S. cumini, S. guineense and S. samarangense. Those are the large public species in the Syzygium genus and some of them have been used as traditional medicines. Different parts (leaves, seeds, fruits, barks, stem barks and flower buds) of each species plant are rich in phytochemical constituents such as flavonoids, terpenoids, tannins, glycosides and phenolics. Antioxidant, antidiabetic, anticancer, toxicity, antimicrobial, anti-inflammatory and anthelmintic activities are reported in various extracts (methanol, ethanol and aqueous) from different parts of Syzygium sp. The bioactivities were studied by using 1,1-diphenyl-2-picrylhydrazyl and ferric reducing antioxidant power assays for antioxidant, 5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazoly)- 3-(4-sulfophenyl) tetrazolium and 3-(4,5-dimethylthiazol- 2-yl)-2-5-diphenyltetrazolium bromide assays for anticancer, α-glucosidase and α-amylase inhibition assays for antidiabetic, agar well diffusion method for antimicrobial and brine shrimp lethality assay for toxicity. Moreover, this review shows that phytochemical constituents of each species significantly presented various bioactivities. Therefore, this review suggests that there is great potential for obtaining the lead drug from these species.
KW - Acylphloroglucinol
KW - Chromone
KW - Flavonoid
KW - Myrtaceae
KW - Phenol
KW - S. aromaticum
KW - S. cumini
KW - S. guineense
KW - S. samarangense
KW - Steroid
KW - Syzygium aqueum
KW - Tannin
KW - Terpenoid
UR - http://www.scopus.com/inward/record.url?scp=85095773957&partnerID=8YFLogxK
U2 - 10.1515/chem-2020-0175
DO - 10.1515/chem-2020-0175
M3 - Review article
AN - SCOPUS:85095773957
SN - 2391-5420
VL - 18
SP - 1256
EP - 1281
JO - Open Chemistry
JF - Open Chemistry
IS - 1
ER -