Phytochemical Compounds and Potential anti-Osteoclastogenesis Effect of Extracted Aloe vera

Sularsih, Sarianoferni, Widyasri Prananingrum, Siswandono

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3 Citations (Scopus)


This study was identified phytochemical compounds of extracted Aloe vera and to analyze anti-osteoclastogenesis activity through the RANK expression and osteoclast cells on socket of tooth extraction of Cavia cobaya. Identification phytochemical compounds used colorimetric methods. Docking analysis to predict binding to TLR-2 receptor. Thirty-six male Cavia cobaya were divided: K (-) was not used scaffold, K (+) with chitosan and P with combination Aloe vera and chitosan. Each group divided into 7 and 14 days observation. Immunohistochemical examination was conducted to examine the RANK expression and Histopathological examination to examine osteoclast cells. The compounds identified in the extracted Aloe vera included flavonoids, saponins, tannins, and anthraquinone. There was hydrogen bonding and steric interaction between Aloe vera and TLR-2 receptor. Anova test showed RANK and osteoclast significant decreased (p?0.05; p=0.00) especially in P compare to K (-) and K (+). LSD Test showed significant differences between the groups. Aloe vera’s compounds have anti-osteoclastogenesis activity and its combination with chitosan decreased the RANK expression and osteoclast on socket healing of Cavia cobaya.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalJournal of International Dental and Medical Research
Issue number1
Publication statusPublished - 2021


  • Aloe vera
  • Phytochemical compounds
  • RANK
  • chitosan
  • osteoclast


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