Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 with Different Lipid Ratios

Nanostructured Lipid Carriers (NLC) could be a good choice for dermal or transdermal delivery. It could dissolve lipophilic drugs, solve the problem of low skin permeation, and also be photoprotective. The composition of constituent materials and the ratio between solid lipid and liquid lipid influence the characteristics and stability of NLC. Compritol 888 ATO and Miglyol 812 have been widely studied for the development of dermal or transdermal preparation, but this combination has not been studied for use in Coenzyme Q10 loaded NLC systems. Aim of this study is to determine the effect of different lipid ratios of Compritol 888 ATO as solid lipid and Miglyol 812 as liquid lipid on the physicochemical characteristics, entrapment efficiency, and stability of NLC loaded Coenzyme Q10 using the High Shear Homogenization method. Three different lipid ratios were used in the NLC formulation, in which the ratio of Compritol 888 ATO: Miglyol 812 were 70:30, 80:20, and 90:10, respectively. NLC was characterized with FTIR spectra, differential scanning calorimetry, organoleptic, particle size, polydispersity index, zeta potential, pH, viscosity, entrapment efficiency, and evaluated for stability using the real-time method for 1 month. The result showed that the polydispersity index, zeta potential, and pH value were not significantly impacted by the various ratios of lipid. On the other hand, it had a considerable impact on particle size, viscosity, and entrapment efficiency. Formula 1 shows highest entrapment efficiency and smallest particle size, so it was chosen as the best formula.