TY - JOUR
T1 - Phenolic compounds from the stem bark of Erythrina orientalis and their cytotoxic and antioxidant activities
AU - Tjahjandarie, Tjitjik Srie
AU - Tanjung, Mulyadi
PY - 2015
Y1 - 2015
N2 - Two prenylated pterocarpans, phaseollin (1), shinpterocarpin (2) together with flavonoids, 4'-O-methyl licoflavanone (3), alpinumisoflavone (4), 8-prenyl-daidzein (5), have been isolated from the stem bark of Erythrina orientalis. The structures of these compounds were determined based on UV, IR, HRESIMS, 1D and 2D NMR data. Compounds 1-5 were evaluated for their cytotoxic properties against P-388 cells, their IC50 values 2.55, 2.43, 17.98, 4.31, and 5.82 μg/mL, respectively. Compounds 1, and 5 exhibited very high antioxidant activity against DPPH radical scavenging.
AB - Two prenylated pterocarpans, phaseollin (1), shinpterocarpin (2) together with flavonoids, 4'-O-methyl licoflavanone (3), alpinumisoflavone (4), 8-prenyl-daidzein (5), have been isolated from the stem bark of Erythrina orientalis. The structures of these compounds were determined based on UV, IR, HRESIMS, 1D and 2D NMR data. Compounds 1-5 were evaluated for their cytotoxic properties against P-388 cells, their IC50 values 2.55, 2.43, 17.98, 4.31, and 5.82 μg/mL, respectively. Compounds 1, and 5 exhibited very high antioxidant activity against DPPH radical scavenging.
KW - Antioxidant
KW - Cytotoxic
KW - Erythrina orientalis
KW - Flavonoid
KW - Pterocarpan
UR - http://www.scopus.com/inward/record.url?scp=84924121920&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84924121920
SN - 0975-413X
VL - 7
SP - 206
EP - 211
JO - Der Pharma Chemica
JF - Der Pharma Chemica
IS - 1
ER -