TY - JOUR
T1 - Pharmacomicrobiomics
T2 - Influence of gut microbiota on drug and xenobiotic metabolism
AU - Dikeocha, Ifeoma Julieth
AU - Al-Kabsi, Abdelkodose Mohammed
AU - Miftahussurur, Muhammad
AU - Alshawsh, Mohammed Abdullah
N1 - Funding Information:
We would like to thank Salah Al Shehade for contributing to the illustration design. This study was funded by Universiti Malaya, research grant number (ST070‐2021) and Internal Universitas Airlangga Research grant.
Publisher Copyright:
© 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
PY - 2022/6
Y1 - 2022/6
N2 - Gut microbiota is the most diverse and complex biological ecosystem, which is estimated to consist of greater than 5 million distinct genes and 100 trillion cells which are in constant communication with the host environment. The interaction between the gut microbiota and drugs and other xenobiotic compounds is bidirectional, quite complicated, and not fully understood yet. The impact of xenobiotics from pollution, manufacturing processes or from the environment is harmful to human health at varying degrees and this needs to be recognized and addressed. The gut microbiota is capable of biotransforming/metabolizing of various drugs and xenobiotic compounds as well as altering the activity and toxicity of these substances, thereby influencing how a host responds to drugs and xenobiotics and this emerging field is known as pharmacomicrobiomics. In this review, we discussed different mechanisms of drug–gut microbiota interaction and highlighted the influence of drug-gut microbiome interactions on the clinical response in humans.
AB - Gut microbiota is the most diverse and complex biological ecosystem, which is estimated to consist of greater than 5 million distinct genes and 100 trillion cells which are in constant communication with the host environment. The interaction between the gut microbiota and drugs and other xenobiotic compounds is bidirectional, quite complicated, and not fully understood yet. The impact of xenobiotics from pollution, manufacturing processes or from the environment is harmful to human health at varying degrees and this needs to be recognized and addressed. The gut microbiota is capable of biotransforming/metabolizing of various drugs and xenobiotic compounds as well as altering the activity and toxicity of these substances, thereby influencing how a host responds to drugs and xenobiotics and this emerging field is known as pharmacomicrobiomics. In this review, we discussed different mechanisms of drug–gut microbiota interaction and highlighted the influence of drug-gut microbiome interactions on the clinical response in humans.
KW - drug metabolism
KW - gut microbiota
KW - microbiome
KW - pharmacomicrobiomics
KW - xenobiotics
UR - http://www.scopus.com/inward/record.url?scp=85130146829&partnerID=8YFLogxK
U2 - 10.1096/fj.202101986R
DO - 10.1096/fj.202101986R
M3 - Review article
C2 - 35579628
AN - SCOPUS:85130146829
SN - 0892-6638
VL - 36
JO - FASEB Journal
JF - FASEB Journal
IS - 6
M1 - e22350
ER -
