Abstract
p-methoxycinnamic acid (pMCA) is a weakly acidic compound that can be isolated from the rhizome of Kaempferia galanga Linn plant. It has a stronger analgesic activity than acetylsalicylic acid and can be developed into a medicinal dosage form. Furthermore, the low solubility of this compound is affected by the pH of the environment. The formation of inclusion complexes with hydroxypropyl-β-cyclodextrin (HPβCD) compounds increases the solubility of pMCA in the presence of large amounts of HPβCD. Therefore, this study aims to evaluate the solubility of pMCA using pH adjustment and the formation of inclusion complexes with HPβCD compounds. Solubility studies without and in the presence of HPβCD using different pH buffer solutions (pH 2.0 - 7.0) were conducted in a water bath shaker at a temperature of 32 ± 0.5°C. In addition, the dissolved pMCA were analyzed by UV-Vis spectrophotometer at the maximum wavelength of each solution pH. The results showed that the solubility of pMCA increased with increasing pH and the presence of HPβCD as an inclusion complex-forming compound can significantly increase the solubility. Furthermore, the results are expected to reduce the use of HPβCD in the development of pMCA dosage forms.
| Original language | English |
|---|---|
| Pages (from-to) | 723-729 |
| Number of pages | 7 |
| Journal | Journal of Chemical Technology and Metallurgy |
| Volume | 57 |
| Issue number | 4 |
| Publication status | Published - 2022 |
Keywords
- Solubility
- hydroxypropyl-β-cyclodextrin
- inclusion complex
- medicine
- p-methoxycinnamic acid
- pH