Defects in the mandible cause deformities, functional disturbances and facial esthetics that cause a decrease in a person's quality of life. Autograft is the gold standard because it has osteogenic, osteoinductive, osteoconductive properties and does not cause an immune response. Allograft as an alternative to autograft is the use of scaffold. The common bovine scaffolds that have been widely studied are DBBM (Deproteinized Bovine Bone Material), FDBB (Freeze-dried bovine bone xenograft) and dc-FDBB (Decellularized freeze-dried bovine bone xenograft). Permeability is a parameter that quantitatively measures the ability of a porous medium to flow liquids and depends on a combination of porosity, pore size, pore distribution and tortuosity. High viscosity can result in higher permeability. The porosity of decellularized cartilage bovine scaffold was significantly increased compared to fresh bovine cartilage. Objectives to find out whether the level of permeability of dc-FDBB qualifies as a bone tissue engineering scaffold. Scaffold FDBB, dc-FDBB, DBBM were divided into 2 groups, namely the group with distilled water and the group with 30% glycerol media. The permeability test was carried out in each group by measuring the liquid discharge every minute for 10 minutes and then calculating the permeability value. Then the permeability comparison between scaffolds is carried out. The maximum volume of fluid flow per minute was found on the DBBM scaffold, both in distilled water and 30% glycerol media. In the group with distilled water and 30% glycerol group, the highest permeability values were obtained in the DBBM scaffold test group, and the lowest in the dc-FDBB test group. The permeability of the dc-FDBB scaffold in this study shows a value that falls within the range of human cancellous bone permeability values so that it can be concluded that the dc-FDBB scaffold in this study meets the scaffold permeability standards for tissue engineering.
|Number of pages||6|
|Journal||Journal of International Dental and Medical Research|
|Publication status||Published - 2022|
- Health care quality
- Tissue engineering