Pengaruh Pemberian Ekstrak Dandang Gendis (Clinacanthus nutans) Terhadap Kadar Glukosa Darah pada Tikus Wistar Model Diabetes Melitus

Translated title of the contribution: The Effect of Dandang Gendis (Clinacanthus nutans) Extracts on Blood Glucose Levels in Wistar Rats Diabetes Mellitus Model

Nena Ristra Dewinta, Indri Safitri Mukono, Arifa Mustika

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Diabetes Mellitus refers to a disease indicated by hyperglycemia due to abnormality in either insulin secretion or action, or both. Dandang gendis leaves (Clinacanthus nutans) is known to contain antioxidants, which is reported to be able to lower blood glucose levels. The present study aimed to find out the effect of giving the extract of C. nutans on the blood glucose of Wistar rat as a diabetic model. Thirty rats that met the criteria were divided into five groups; they were then induced by hyperglycemia using Streptozocin (STZ) 50 mg/kg. Two days after the induction, the rats were treated using C. nutans extract with the dosage of K1 (75 mg/kgBW), K2 (150 mg/kgBW), and K3 (300 mg/kgBW), then they are compared to K0 (CMC-Na as the control) and K4 (metformin as standard medication) for fourteen days. The most significant decrease of blood glucose was found in the group that was treated using 75mg/kg of C. nutans extract, compared to the K0, K2, K3, and K4.

Translated title of the contributionThe Effect of Dandang Gendis (Clinacanthus nutans) Extracts on Blood Glucose Levels in Wistar Rats Diabetes Mellitus Model
Original languageIndonesian
Pages (from-to)76-81
Number of pages6
JournalJurnal Medik Veteriner
Volume3
Issue number1
DOIs
Publication statusPublished - Apr 2020

Keywords

  • Clinacanthus nutans
  • Diabetes mellitus
  • Hyperglycemia

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