Abstract
This study aimed to identify the pulmo histopathology figure of albino rats exposured to an e-cigarette. A total of 20 rats divided in 5 groups, control group (K) were not exposed by e-cigarette and treatment group were exposed by e-cigarette in different doses, P1 (0,3mg/ml), P2 (3mg/ml), P3 (12 mg/ml), P4 (36 mg/ml) respectively. After 14 days of treatment, rats were euthanasia and necropsy method was performed to identify macroscopy change, also the pulmo organs were dissected and preserved for histopathological study using Hematoxilin-Eosin staining. The results showed that damage of pulmo was defected within histopathology examination using 400x magnification. Moreover, the data were analyzed using Kruskal-Wallis test and continued by Mann Whitney Test which s how a significant difference (p<0.05). Average result from pulmo organs of Rats were Control (K)=3.00; (P1)=6.00; (P2)=12.00; (P3)=13.00 and (P4)=18.50 and nicotine dose of minimum was 3 mg/ml. In conclusion, the exposure of an e-cigarette have significant damage effect of pulmo organs in rats.
Translated title of the contribution | The Effect of Electric Cigarette Exposure on The Histopathology of Pulmo in Albino Rats (Rattus norvegicus) |
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Original language | Indonesian |
Pages (from-to) | 38-44 |
Number of pages | 7 |
Journal | Jurnal Medik Veteriner |
Volume | 3 |
Issue number | 1 |
DOIs | |
Publication status | Published - Apr 2020 |
Keywords
- Rattus norvegicus
- e-cigarettes
- histophatology
- pulmo