Background: Sepsis and shock septic still is one of the causes of morbidity and mortality that many in pediatric patients. The study is intended to determine the effectiveness of the systems Pediatric Risk of Mortality-IV(PRISM-IV), Pediatric Logistic Organ Dysfunction-2 (PELOD-2) and Pediatric Index of Mortality-3 (PIM-3) in predicting the outcome of patients. Methods: Data were taken from the medical record of patients. Medical records are then evaluated using the inclusion criteria and the criteria for exclusion. Data is processed statistically. Result: The number of survived subjects was 38 patients and the number of deaths was 26 patients. The regression test showed that to a relationship that significant between the value of scoring PRISM-IV against mortality with p 0.001 (p <0.05 CI 95%). The PIM-3 score was analyzed. The regression test showed that there is no significant relationship between the score PIM-3 against mortality with p 0.371 (p <0.05 CI 95%). Test relationship score PELOD-2 against mortality showed that patients who survived had a value score of PELOD 0, whereas the patients who died had a mean score of 3.6 (SD ± 4.5). The results of the test regression showed a significant relationship with p 0.018 ( (p <0.05 CI 95%) with the strength of the relationship R = 0.595. Conclusion: The PELOD-2 and PRISM-IV grading systems are equally good at predicting the outcome of pediatric surgical patients with sepsis. The PELOD-2 system has advantages in specificity and accuracy, while the PRISM-IV system has an advantage in sensitivity.