Extreme bone resorption of the mandible and maxilla may produce an unstable or a non-retentive denture and is associated with pain and discomfort. Knife edge ridge is one of compromised ridge due to resorbtion ridge process. Knife edge ridge is a ridge with sharp bones and is a frequent problem in edentulous patients. Influence in the bone structure of the residual ridge may be the cause of chronic pain under the denture, especially when performing mastication movements. When this ridge knife edge is loaded, the existing mucosa is pinched between the denture base and the bone which then causes the pain. To find out the mechanism of pain occurring in the edentulous knife edge ridge given complete denture treatment. Knife edge ridge that was given a complete denture treatment can trigger the occurrence of pain. The process of the occurrence of pain occurs in 4 phases of transduction, transmission, perception and modulation, which in the process requires neurotransmitters such as substance P (sP) and ATP as messenger pain.

Original languageEnglish
Pages (from-to)3071-3074
Number of pages4
JournalBiochemical and Cellular Archives
Publication statusPublished - 2020


  • Complete denture
  • Illness
  • Knife edge ridge
  • Pain


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