TY - JOUR
T1 - Overview of therapeutic changes in antiepileptic drugs in adult patients
AU - Ratri, Dinda M.N.
AU - Rahmadi, Mahardian
AU - Islamiyah, Wardah R.
AU - Harum, Nur Faridah
N1 - Publisher Copyright:
© 2019 2019 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Previous studies suggest a highly variable response of antiepileptic drugs (AEDs). This may be because the response to AEDs has been changed to sustained period of freedom from seizures. This study was conducted to determine whether therapeutic changes of AEDs in the treatment of seizure would be observable in an Indonesian population. The study was conducted at the outpatient neurology polyclinic at the Universitas Airlangga Hospital, Surabaya, Indonesia. This was an observational retrospective cohort study, examining the outcomes of 41 cases of switching AEDs (increase or decrease of the dose, switch to branded or generic, or added or reduced type of AEDs). After treatment with the switched AED, seizure did not show any significant improvement. However, the incidence of seizure during and after the therapeutic change showed a downward trend (from 44% to 32%). According to the present study, mere optimization of antiepileptic therapy may not result in a steep decrease in seizure events, particularly in polytherapy with AEDs. On the other hand, monotherapy with AEDs evidences to decreasing tendency of seizures.
AB - Previous studies suggest a highly variable response of antiepileptic drugs (AEDs). This may be because the response to AEDs has been changed to sustained period of freedom from seizures. This study was conducted to determine whether therapeutic changes of AEDs in the treatment of seizure would be observable in an Indonesian population. The study was conducted at the outpatient neurology polyclinic at the Universitas Airlangga Hospital, Surabaya, Indonesia. This was an observational retrospective cohort study, examining the outcomes of 41 cases of switching AEDs (increase or decrease of the dose, switch to branded or generic, or added or reduced type of AEDs). After treatment with the switched AED, seizure did not show any significant improvement. However, the incidence of seizure during and after the therapeutic change showed a downward trend (from 44% to 32%). According to the present study, mere optimization of antiepileptic therapy may not result in a steep decrease in seizure events, particularly in polytherapy with AEDs. On the other hand, monotherapy with AEDs evidences to decreasing tendency of seizures.
KW - antiepileptic drugs
KW - brand versus generic
KW - decreased dose
KW - increased dose
KW - switch
UR - http://www.scopus.com/inward/record.url?scp=85078338075&partnerID=8YFLogxK
U2 - 10.1515/jbcpp-2019-0346
DO - 10.1515/jbcpp-2019-0346
M3 - Article
C2 - 31926092
AN - SCOPUS:85078338075
SN - 0792-6855
VL - 30
JO - Journal of Basic and Clinical Physiology and Pharmacology
JF - Journal of Basic and Clinical Physiology and Pharmacology
IS - 6
M1 - 20190346
ER -