TY - JOUR
T1 - Oral ulcer healing after treatment with distilled liquid smoke of coconut shell on diabetic rats
AU - Surboyo, Meircurius Dwi Condro
AU - Ernawati, Diah Savitri
AU - Arundina, Ira
AU - Rahayu, Retno Pudji
N1 - Publisher Copyright:
© Journal of Krishna Institute of Medical Sciences University.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Background: Distilled liquid smoke from coconut shell (Cocos nucifera L.) by pyrolysis process with final temperature 400°C and then distilled in 120-150°C. The characteristics of distilled liquid smoke are yellow liquid, with acidity 2.39 and density 1.0643 g/cm3. The major identified compounds arephenol (36.6%), 2- methoxyphenol (guaiacol) (25.2%), furfural (17.8%), 2-methoxy-5-methylphenol (5.2%) and 4-ethyl-2- methoxyphenol (EMP) (3.5%) with 28 other minor constituents by GCMS. Aim and Objectives: Distilled liquid smoke was examined to investigate its potential therapeutic to oral ulcer healing and diabetic condition on the rat. Furthermore, the clinical oral ulcer healing was evaluated based on ulcer size and diabetic was evaluated based on Fasting Blood Glucose (FBG) and body weight changes. Material and Methods: Diabetes was induced by alloxan. Seventy-two hours after injection, the diabetic condition was confirmed with FBG of >200mg/dl, then the labial fornix anterior was injured to induce oral ulcer using round steel blade. Results: The clinical oral ulcer healing was improved after treatment with distillated liquid smoke compared to benzydamine hydrochloride and aquadest sterile for three days (p=0.005) and seven days (p=0.000). Treatment for seven days with distilled liquid smoke showed significant improvement of the body mass changes compared to benzydamine hydrochloride (p=0.008) and aquadest sterile (p=0.002). There was no improvement of FBG after treatment with distilled liquid smoke (p=0.152). Conclusion: Treatment with distilled liquid smoke coconut shell can improved oral ulcer healing and body weight changes, but not FBG changes.
AB - Background: Distilled liquid smoke from coconut shell (Cocos nucifera L.) by pyrolysis process with final temperature 400°C and then distilled in 120-150°C. The characteristics of distilled liquid smoke are yellow liquid, with acidity 2.39 and density 1.0643 g/cm3. The major identified compounds arephenol (36.6%), 2- methoxyphenol (guaiacol) (25.2%), furfural (17.8%), 2-methoxy-5-methylphenol (5.2%) and 4-ethyl-2- methoxyphenol (EMP) (3.5%) with 28 other minor constituents by GCMS. Aim and Objectives: Distilled liquid smoke was examined to investigate its potential therapeutic to oral ulcer healing and diabetic condition on the rat. Furthermore, the clinical oral ulcer healing was evaluated based on ulcer size and diabetic was evaluated based on Fasting Blood Glucose (FBG) and body weight changes. Material and Methods: Diabetes was induced by alloxan. Seventy-two hours after injection, the diabetic condition was confirmed with FBG of >200mg/dl, then the labial fornix anterior was injured to induce oral ulcer using round steel blade. Results: The clinical oral ulcer healing was improved after treatment with distillated liquid smoke compared to benzydamine hydrochloride and aquadest sterile for three days (p=0.005) and seven days (p=0.000). Treatment for seven days with distilled liquid smoke showed significant improvement of the body mass changes compared to benzydamine hydrochloride (p=0.008) and aquadest sterile (p=0.002). There was no improvement of FBG after treatment with distilled liquid smoke (p=0.152). Conclusion: Treatment with distilled liquid smoke coconut shell can improved oral ulcer healing and body weight changes, but not FBG changes.
KW - Alloxan
KW - Coconut shell
KW - Diabetic
KW - Distilled liquid smoke
KW - Oral ulcer healing
UR - http://www.scopus.com/inward/record.url?scp=85068501033&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85068501033
SN - 2231-4261
VL - 8
SP - 70
EP - 79
JO - Journal of Krishna Institute of Medical Sciences University
JF - Journal of Krishna Institute of Medical Sciences University
IS - 2
ER -