Oral syphilis as potential lesion lead to malignancy

Evidence based potential oral syphilis lead to malignancy. The objectives of this study is to evaluate the probable risk of oral carcinoma caused by syphilis. Recent study found syphilis could lead to malignant syphilis with clinical features ulcerated plaque and nodules which appear symmetrical, covered by dense crust attached. Smooth surfaces of the tongue with sharp grayish patch. There's chance to find nodulo-ulcerative lesions over the face. Hyperkeratotic papules over bilateral palms. Histopathological inspection showing a mix of thick of plasma cells with histiocytes and lymphocytes penetrated in the dermis. The risk of syphilis develop into malignancy multiplied by 60 times with the presence of HIV infection. It is necessarily aware of this disease by the increase of syphilis with HIV infection incidence. Clinicians should be more aware of the syphilis incidence because of its capability to manifested in oral and perioral region, moreover it's high chance of malignancy.