TY - JOUR
T1 - Oral field cancerization
T2 - Genetic profiling for a prevention strategy for oral potentially malignant disorders
AU - Puspasari, Karlina
AU - Pasaribu, Togu Andrie Simon
AU - Surboyo, Meircurius Dwi Condro
AU - Ayuningtyas, Nurina Febriyanti
AU - Santosh, Arvind Babu Rajendra
AU - Ernawati, Diah Savitri
N1 - Publisher Copyright:
Copyright © 2023 Dental Journal (Majalah Kedokteran Gigi).
PY - 2023/9
Y1 - 2023/9
N2 - Background: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (OPMDs). Patients diagnosed with OPMDs may have an increased risk of developing cancer anywhere in the oral cavity. Early detection and intervention could be essential prevention strategies to inhibit oral cancer progression. OPMDs may not immediately develop into carcinoma. However, this condition provides a “field” of specific abnormalities wherein evolving altered genetic cells can be explained with the “field cancerization” concept. Purpose: This review aims to describe the “field cancerization” concept in oral cancer and OPMD, which is expected to contribute to a better clinical management strategy for oral cancer prevention. Review: “Oral field cancerization” describes oral cancers that develop in multifocal areas of pre-cancerous changes. It can be found as histologically abnormal tissue surrounding the tumor, suggesting that oral cancer often consists of multiple independent lesions. Conclusion: The oral field cancerization concept should prompt healthcare professionals to remind their patients that frequent oral examination with histological studies and molecular testing is mandatory for those at high risk of developing malignancies.
AB - Background: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (OPMDs). Patients diagnosed with OPMDs may have an increased risk of developing cancer anywhere in the oral cavity. Early detection and intervention could be essential prevention strategies to inhibit oral cancer progression. OPMDs may not immediately develop into carcinoma. However, this condition provides a “field” of specific abnormalities wherein evolving altered genetic cells can be explained with the “field cancerization” concept. Purpose: This review aims to describe the “field cancerization” concept in oral cancer and OPMD, which is expected to contribute to a better clinical management strategy for oral cancer prevention. Review: “Oral field cancerization” describes oral cancers that develop in multifocal areas of pre-cancerous changes. It can be found as histologically abnormal tissue surrounding the tumor, suggesting that oral cancer often consists of multiple independent lesions. Conclusion: The oral field cancerization concept should prompt healthcare professionals to remind their patients that frequent oral examination with histological studies and molecular testing is mandatory for those at high risk of developing malignancies.
KW - genetically altered field
KW - oral cancer
KW - oral field cancerization
KW - oral potentially malignant disorders
UR - http://www.scopus.com/inward/record.url?scp=85166234751&partnerID=8YFLogxK
U2 - 10.20473/j.djmkg.v56.i3.p189-196
DO - 10.20473/j.djmkg.v56.i3.p189-196
M3 - Review article
AN - SCOPUS:85166234751
SN - 1978-3728
VL - 56
SP - 189
EP - 196
JO - Dental Journal
JF - Dental Journal
IS - 3
ER -