Optimum concentration anredera cordifolia (Ten.) steenis gel in increasing the expression BMP-2 and the number of osteoblasts post tooth extraction in wistar rats

Healing or recovery of damaged tissue basically is a replacement of the damaged tissue with the new ones to become normal tissue. The process of tissue recovery is the first stage of dynamic processes. The healing process is important for normal structure maintenance, function, and life perpetuity of an individual, one of which has important role is fibroblast and osteoblast. Anredera cordifolia (Ten.) Steenis leaf is a local plant that frequently used as medicinal treatments in Indonesia was also known as binahong leaf, some of them to heal wounds, but there had never been research of the use of its leaf in wound recovery after tooth extraction especially in BMP-2 and osteoblast proliferation. The aim of this study was to investigate the effect of A. cordifolia (Ten.) Steenis gel in accelerating the expression of BMP-2 and the number of Osteoblasts post tooth extraction in Wistar Rats. This study was used post test only control group design. 36 male Wistar Rats weight between 150-200 grams, 3 months of age are being used. Tooth extraction is being done on lower left incisor. The 36 rats are divided into three groups. The data were analyzed statistically using One-Way ANOVA and LSD 0.05. The result of every tested group showed p > 0.05, therefore all the data had a normal distribution. Therefore, a One-Way Anova test with 5% significant rate was done and continued by LSD test to find a significant difference in each groups. Examination showed there was significant difference in expression BMP-2 and the number of Osteoblasts between A. cordifolia (Ten.) Steenis gel 10% and two other groups (p < 0.05). The application of A. cordifolia (Ten.) Steenis gel 10% can accelerate the expression BMP-2 and the number of Osteoblasts post tooth extraction in Wistar Rats.