TY - GEN
T1 - OPG and RANKL expression after application of hydroxyapatite tooth graft
AU - Anitasari, Winidiastuti
AU - Sunnu, Vanda Valentina
AU - Wibisono, Poernomo Agoes
AU - Krismariono, Agung
N1 - Publisher Copyright:
© 2020 Author(s).
PY - 2020/12/9
Y1 - 2020/12/9
N2 - Periodontal disease can be treated with a surgical procedure using a bone graft. Tooth graft is an alternative graft for Guided Tissue Regeneration because tooth graft consists of organic and inorganic materials which are very similar to bone. The purpose of this study was to analyze the potential of hydroxyapatite from tooth graft as an alternative for conventional bone graft using OPG and RANKL as parameters. This research is a study on Wistar mice by post only control group design. In this study, 18 Wistar mice divided into 2 groups, control group, and tooth graft groups. On the tooth graft group, the mice socket post extraction was filled with hydroxyapatite, while the sockets from the control group were left untreated. OPG and RANKL expressions were analyzed on the fourteenth day after the application of hydroxyapatite. Independent T-test is used to analyze the results. The result of the expression of OPG between the control group and the tooth graft group showed that p<0,05 which mean that there was a significant difference. The result of the expression of RANKL between the control group and the tooth graft group showed that p<0,05 which mean that there was a significant difference. The expression of OPG and RANKL in the tooth graft group showed that p>0,05, which mean there was no significant difference. From this study can be concluded that the hydroxyapatite tooth graft is able to enhance the expression of OPG and RANKL.
AB - Periodontal disease can be treated with a surgical procedure using a bone graft. Tooth graft is an alternative graft for Guided Tissue Regeneration because tooth graft consists of organic and inorganic materials which are very similar to bone. The purpose of this study was to analyze the potential of hydroxyapatite from tooth graft as an alternative for conventional bone graft using OPG and RANKL as parameters. This research is a study on Wistar mice by post only control group design. In this study, 18 Wistar mice divided into 2 groups, control group, and tooth graft groups. On the tooth graft group, the mice socket post extraction was filled with hydroxyapatite, while the sockets from the control group were left untreated. OPG and RANKL expressions were analyzed on the fourteenth day after the application of hydroxyapatite. Independent T-test is used to analyze the results. The result of the expression of OPG between the control group and the tooth graft group showed that p<0,05 which mean that there was a significant difference. The result of the expression of RANKL between the control group and the tooth graft group showed that p<0,05 which mean that there was a significant difference. The expression of OPG and RANKL in the tooth graft group showed that p>0,05, which mean there was no significant difference. From this study can be concluded that the hydroxyapatite tooth graft is able to enhance the expression of OPG and RANKL.
UR - http://www.scopus.com/inward/record.url?scp=85097990786&partnerID=8YFLogxK
U2 - 10.1063/5.0036107
DO - 10.1063/5.0036107
M3 - Conference contribution
AN - SCOPUS:85097990786
T3 - AIP Conference Proceedings
BT - 2nd International Conference on Physical Instrumentation and Advanced Materials 2019
A2 - Trilaksana, Herri
A2 - Harun, Sulaiman Wadi
A2 - Shearer, Cameron
A2 - Yasin, Moh
PB - American Institute of Physics Inc.
T2 - 2nd International Conference on Physical Instrumentation and Advanced Materials, ICPIAM 2019
Y2 - 22 October 2019
ER -