Occurrence of Carriage of Multidrug Resistant Enterobacteriaceae among Pregnant Women in the Primary Health Center and Hospital Setting in Surabaya, Indonesia

Siti Rochmanah Oktaviani Sulikah, Miratul Hasanah, Wahyu Setyarini, Hari Parathon, Koichi Kitagawa, Noriko Nakanishi, Ryohei Nomoto, Kayo Osawa, Shohiro Kinoshita, Itaru Hirai, Toshiro Shirakawa, Kuntaman Kuntaman

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The incidence of healthy individuals carrying multidrug resistant Enterobacteriaceae, including extended-spectrum β-lactamase producing Enterobacteriaceae (ESBL-E), especially extended-spectrum β-lactamase producing Escherichia coli (ESBL-EC) and extended-spectrum β-lactamase producing Klebsiella pneumoniae (ESBL-KP), is increasing worldwide. Although ESBL-E causes early or late onset of neonatal sepsis, the prevalence of ESBL-E carriage among pregnant women in Indonesia is not clear. In the present study, we compared the occurrence of carriage of ESBL-E among pregnant women in a primary health center (PHC) versus two hospitals. Materials and Methods: We collected rectal swab samples from 200 pregnant women who visited a PHC or were admitted to two hospitals in Surabaya, Indonesia from July to October 2018. The ESBL-E strains were isolated from the samples and phenotypically and genotypically analyzed. Results: ESBL-E strains were isolated from 25 (24.8%) pregnant women who visited the PHC and 49 (49.5%) pregnant women who were admitted to the hospitals. The rate of ESBL-E carriage of pregnant women in the hospitals was significantly higher than that in the PHC. Among the 74 isolated ESBL-E strains, ESBL-EC was most frequently isolated (62 strains), followed by ESBL-KP (12 strains). In addition, blaCTX-M-15 was the most frequent ESBL gene type of the isolated ESBL-E strains. Conclusions: Our results revealed the high occurrence of ESBL-E carriage in pregnant women, especially those who were admitted to the hospitals.

Original languageEnglish
Pages (from-to)48-55
Number of pages8
JournalMicrobial Drug Resistance
Volume28
Issue number1
DOIs
Publication statusPublished - 1 Jan 2022

Keywords

  • ESBL
  • Indonesia
  • MLST
  • PFGE
  • fecal carriage
  • phylogenetic group
  • pregnant woman

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