TY - JOUR
T1 - Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults
T2 - A Meta-Analysis
AU - Khosravaniardakani, Sheida
AU - Bokov, Dmitry Olegovich
AU - Mahmudiono, Trias
AU - Hashemi, Seyedeh Sedigheh
AU - Nikrad, Negin
AU - Rabieemotmaen, Shadi
AU - Abbasalizad-Farhangi, Mahdieh
N1 - Funding Information:
We are thankful from Student Research Committee, Tabriz University of Medical Sciences for their financial support. The present study has been performed by a grant from Student Research Committee, Tabriz University of Medical Sciences (Grant number: 68733; Identifier: IR.TBZMED.VCR.REC.1400.471).
Publisher Copyright:
Copyright © 2022 Khosravaniardakani, Bokov, Mahmudiono, Hashemi, Nikrad, Rabieemotmaen and Abbasalizad-Farhangi.
PY - 2022/5/26
Y1 - 2022/5/26
N2 - Background: Shorter telomere length is associated with numerous comorbidities. Several studies have investigated the role of obesity in telomere shortening. In the current systematic review and meta-analysis, we summarized the results of studies that evaluated the association between obesity and telomere length. Methods: A systematic search from Scopus, PubMed, Embase, and ProQuest electronic databases up to 19 March 2021 without language restriction was performed and after data extraction and screening, 19 manuscripts were eligible to be included in the final meta-synthesis. Results: The highest category of telomere length was associated with an approximate 0.75 kg/m2 reduction in body mass index (BMI; WMD = −0.75 kg/m2; CI = −1.19, −0.31; p < 0.001; I2 = 99.4%). Moreover, overweight/obese individuals had 0.036 kbp shorter telomere length compared with non-overweight/obese adults (WMD = −0.036; CI = −0.05, −0.02; p = 0.030; I2 = 100%). According to the results of subgroupings, continent, age, and sample size could be possible sources of heterogeneity. Conclusion: From the results, it was clear that obesity was associated with shorter telomere length. Because of the observational design of included studies, the causality inference of results should be done with caution; thus, further longitudinal studies are warranted for better inference of causal association.
AB - Background: Shorter telomere length is associated with numerous comorbidities. Several studies have investigated the role of obesity in telomere shortening. In the current systematic review and meta-analysis, we summarized the results of studies that evaluated the association between obesity and telomere length. Methods: A systematic search from Scopus, PubMed, Embase, and ProQuest electronic databases up to 19 March 2021 without language restriction was performed and after data extraction and screening, 19 manuscripts were eligible to be included in the final meta-synthesis. Results: The highest category of telomere length was associated with an approximate 0.75 kg/m2 reduction in body mass index (BMI; WMD = −0.75 kg/m2; CI = −1.19, −0.31; p < 0.001; I2 = 99.4%). Moreover, overweight/obese individuals had 0.036 kbp shorter telomere length compared with non-overweight/obese adults (WMD = −0.036; CI = −0.05, −0.02; p = 0.030; I2 = 100%). According to the results of subgroupings, continent, age, and sample size could be possible sources of heterogeneity. Conclusion: From the results, it was clear that obesity was associated with shorter telomere length. Because of the observational design of included studies, the causality inference of results should be done with caution; thus, further longitudinal studies are warranted for better inference of causal association.
KW - adult
KW - meta-analysis of hypothesis
KW - obesity
KW - systematic literature search
KW - telomere length
UR - http://www.scopus.com/inward/record.url?scp=85132819239&partnerID=8YFLogxK
U2 - 10.3389/fnut.2022.812846
DO - 10.3389/fnut.2022.812846
M3 - Article
AN - SCOPUS:85132819239
SN - 2296-861X
VL - 9
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
M1 - 812846
ER -
