TY - JOUR
T1 - Nystatin profile on Candida species in HIV/AIDS patients with oral candidiasis
T2 - A phenomenology study
AU - Murtiastutik, Dwi
AU - Maharani, Cut Shelma
AU - Rahmadewi,
AU - Listiawan, Muhammad Yulianto
N1 - Funding Information:
Special thanks to Hastika Saraswati, MD who has assisted in our paper translate and Bernadya Yogatri Anjuwita Saputri, MD who helped us in the research. In addition, we would like to thank the Surabaya Health Laboratory, Indonesia, for helping us to carry out fluconazole resistance tests.
Publisher Copyright:
© The Author(s) 2019. Open Access.
PY - 2019
Y1 - 2019
N2 - Oral candidiasis is the main symptom that often appears in patients with Human Immunodeficiency Virus (HIV) / Acquired Immune Syndrome (AIDS). Recent studies reported that some bacteria causing oral candidiasis are resistant to antifungal drugs. Describing nystatin profile against candida species in HIV / AIDS patients with oral candidiasis. Twenty-nine subjects were divided into 2 groups based on sex (23 male subjects and 6 female subjects). Subjects carried out tissue culture procedure and were tested for sensitivity to fluconazole and nystatin. The analysis was conducted by comparing sex and type of infecting bacteria. Statistical analysis used chi-square test, fisher, or ANOVA with 95% CI with p <0.05. The average age of male and female subjects was 43.15 ± 3.67 years and 40.02 ± 10.23 years, respectively, with age range of 18-65 years. Recurrent oral candidiasis in male and female patients was 65.22% and 83.33%, respectively (p = 0.079). Subjects were resistant to fluconazole as much as 77.50% in men and 61.54% in women (p = 0.823). On the other hand, subjects sensitive to nystatin were 92.50% in men and 92.31% in women (p = 0.167). Fluconazole was resistant to Candida albicans (68.00%) and non-Candida albicans (78.57%) (p = 0.048), while nystatin was sensitive to Candida albicans (92.00%) and non-Candida albicans (92.86%) (p = 0.791). Most subjects were resistant to fluconazole, while the majority of subjects were sensitive to nystatin.
AB - Oral candidiasis is the main symptom that often appears in patients with Human Immunodeficiency Virus (HIV) / Acquired Immune Syndrome (AIDS). Recent studies reported that some bacteria causing oral candidiasis are resistant to antifungal drugs. Describing nystatin profile against candida species in HIV / AIDS patients with oral candidiasis. Twenty-nine subjects were divided into 2 groups based on sex (23 male subjects and 6 female subjects). Subjects carried out tissue culture procedure and were tested for sensitivity to fluconazole and nystatin. The analysis was conducted by comparing sex and type of infecting bacteria. Statistical analysis used chi-square test, fisher, or ANOVA with 95% CI with p <0.05. The average age of male and female subjects was 43.15 ± 3.67 years and 40.02 ± 10.23 years, respectively, with age range of 18-65 years. Recurrent oral candidiasis in male and female patients was 65.22% and 83.33%, respectively (p = 0.079). Subjects were resistant to fluconazole as much as 77.50% in men and 61.54% in women (p = 0.823). On the other hand, subjects sensitive to nystatin were 92.50% in men and 92.31% in women (p = 0.167). Fluconazole was resistant to Candida albicans (68.00%) and non-Candida albicans (78.57%) (p = 0.048), while nystatin was sensitive to Candida albicans (92.00%) and non-Candida albicans (92.86%) (p = 0.791). Most subjects were resistant to fluconazole, while the majority of subjects were sensitive to nystatin.
KW - Candida albicans
KW - Fluconazole
KW - HIV/AIDS
KW - Nystatin
KW - Oral candidiasis
UR - http://www.scopus.com/inward/record.url?scp=85079199880&partnerID=8YFLogxK
U2 - 10.22207/JPAM.13.4.12
DO - 10.22207/JPAM.13.4.12
M3 - Article
AN - SCOPUS:85079199880
SN - 0973-7510
VL - 13
SP - 2013
EP - 2019
JO - Journal of Pure and Applied Microbiology
JF - Journal of Pure and Applied Microbiology
IS - 4
ER -
