Introduction: Salmonella typhi is a facultative intracellular bacterium causing typhoid fever, characterized by symptoms of headache, dizziness, muscle aches, anorexia, nausea, vomiting, and diarrhea. An alternative treatment used to treat the infections caused by Salmonella typhi other than using antibiotics is increasing the body’s immune system. Spirulina platensis is a bluish-green microalgae with several benefits, one of which is an immunomodulator. The aim of the study was to determine the number of peritoneal macrophages of mice induced by Salmonella typhi after the administration of Spirulina platensis. Material and methods: The research method used is Experimental Laboratory with Post Test Only-Control Group Design. The treatment was conducted using 24 mice divided into 4 groups. Variations in the doses of Spirulina plantesis given are 400 mg/KgBW and 800 mg/KgBW. Peritoneal macrophage cells in this study were examined using a Haemocytometer. Result: There is an influence on peritoneal macrophages of mice induced by Salmonella typhi after the addition of Spirulina platensis, with lower numbers of macrophages in treatment groups compared to the positive control group. Conclusion: Spirulina platensis can affect the number of peritoneal macrophages in mice induced by Salmonella typhi.
|Number of pages||4|
|Journal||Malaysian Journal of Medicine and Health Sciences|
|Publication status||Published - Feb 2023|
- Peritoneal macrophage
- Salmonella typhi
- Spirulina platensis