Novel cha2 ds2-vasc-hsf is superior to chads2 and cha2ds2-vasc score to predict the risk of severe coronary artery disease

Andrianto Andrianto, Benny Jovie, Makhyan Jibril Al-Farabi, Parama Gandi, Khubay Alvia Shonafi, Rofda Lathifah

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

BACKGROUND: Various risk scoring methods are available to predict the severity of coronary artery disease (CAD). However, the majority of them are complex and require advanced technologies, thus limiting its usage in primary care settings. CHA2 DS2-VASc-HSF is a novel risk scoring which we develop from CHA2 DS2-VASc score. AIM: We hypothesize that CHA2 DS2-VASc-HSF is predictive for the risk of severe CAD, and we compare its validity with previously established CHADS2 and CHA2 DS2-VASc score. MATERIALS AND METHODS: A total of 210 patients who underwent elective coronary angiography were enrolled in our study. Anthropometric, laboratory, angiographic findings, and patient history were obtained from medical records and used to calculate CHA2 DS2-VASc-HSF score. Severe CAD defined as coronary artery occlusion with the Gensini score of ≥20. Statistical analyses were done using SPSS 25.0 and MedCalc 18.2.1. RESULTS: This research showed that the patient with severe CAD has significantly higher CHADS2, CHA2 DS2-VASc, and CHA2 DS2-VASc-HSF score compared to normal and mild CAD (p < 0.001). CHADS2, CHA2 DS2-VASc, and CHA2 DS2-VASc-HSF correlated significantly with the CAD severity (r = 0.315, p ≤ 0.001; r = 0.395, p ≤ 0.001; r = 0.612, p ≤ 0.001, respectively). CHA2 DS2-VASc-HSF may predict the risk of severe CAD independent from other variables (odds ratio = 2.540; 95% confidence interval = 1.794–3.595; p = 0.002) with the cutoff value of ≥2.5 (sensitivity = 81.4% and specificity = 68.1%). Pairwise comparison of receiver operating characteristic curves showed that CHA2 DS2-VASc-HSF was superior to predict severe CAD. CONCLUSIONS: CHA2 DS2-VASc-HSF scores may predict the risk of severe CAD better than CHADS2 and CHA2 DS2-VASc score. This score may easily be used in primary care physicians to predict the risk of severe CAD and provide an early referral to the cardiologist.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalOpen Access Macedonian Journal of Medical Sciences
Volume8
Issue numberB
DOIs
Publication statusPublished - 2020

Keywords

  • Atherosclerosis
  • Coronary occlusion
  • Gensini score
  • Risk stratification

Fingerprint

Dive into the research topics of 'Novel cha2 ds2-vasc-hsf is superior to chads2 and cha2ds2-vasc score to predict the risk of severe coronary artery disease'. Together they form a unique fingerprint.

Cite this