Non-invasive ventilation in neuromuscular disease with acute respiratory failure: A narrative review

Mia Elhidsi, Dyah Ayu Kusumoputri Buwono, Eka Musridharta, Dicky Soehardiman, Prasenohadi

Research output: Contribution to journalReview articlepeer-review


Acute respiratory failure (ARF) is a life-threatening condition that often results from the acute onset of neuromuscular disease (NMD) and often coexists with other cardiorespiratory conditions. For more than two decades, existing studies have shown that non-invasive ventilation (NIV) is the main ventilatory support and provides a good clinical outcome in ARF with various conditions, but its use in NMD patients with ARF is still limited. In patients with ARF, NIV can be initiated in fully awake patients with hemodynamically stable, without upper airway obstruction, and airway secretions can be overcome. Furthermore, expiratory positive airway pressure (EPAP) and inspiratory positive airway pressure (IPAP) settings with backup rates are recommended. Additionally, some studies have reported that the application of NIV in NMD with ARF can also be beneficial as a weaning strategy. Hence, further studies need to be conducted to generate evidence regarding the role of NIV in NMD patients with ARF.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalRomanian Journal of Neurology/ Revista Romana de Neurologie
Issue number3
Publication statusPublished - 2022
Externally publishedYes


  • Acute Respiratory Failure
  • Neuromuscular Disease
  • Non-invasive Ventilation


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