Abstract
Glioblastoma is a malignant neoplasm of the central nervous system with an abysmal prognosis despite maximum standard therapy. Electro-capacitive cancer therapy (ECCT) is a non-contact electric field therapy popularized in Indonesia. This study aims to explore the effect of ECCT on TNF-a level in glioblastoma cell line in vitro as a representation of inflammatory response. This study was done by exposing an non-contact electric field to the U87-MG cell line at three electricity doses (10, 30, and 50 peak-to-peak voltage (Vpp)) and time (24, 48, and 72 hours). TNF-a was examined using western blot after exposure. TNF-a level in the U87-MG cell line raised after 24 hours of exposure, despite not being statistically significant. After 24 hours, TNF-a level gradually decreased over time.
| Original language | English |
|---|---|
| Pages (from-to) | 313-320 |
| Number of pages | 8 |
| Journal | Journal of Medicinal and Pharmaceutical Chemistry Research |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2025 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Electric field therapy
- TNF-a
- cell line
- glioblastoma
- inflammation
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