TY - JOUR
T1 - Non-contact electric fields’ effect on TNF-a in glioblastoma cell line
T2 - An experimental study
AU - Meizikri, Rizki
AU - Haq, Irwan Barlian Immadoel
AU - Suryaningtyas, Wihasto
AU - Purwati, Purwati
AU - Parenrengi, Muhammad Arifin
AU - Wahyuhadi, Joni
AU - Utomo, Budi
AU - Taruno, Warsito
N1 - Publisher Copyright:
© 2025, Sami Publishing Company. All rights reserved.
PY - 2025/2
Y1 - 2025/2
N2 - Glioblastoma is a malignant neoplasm of the central nervous system with an abysmal prognosis despite maximum standard therapy. Electro-capacitive cancer therapy (ECCT) is a non-contact electric field therapy popularized in Indonesia. This study aims to explore the effect of ECCT on TNF-a level in glioblastoma cell line in vitro as a representation of inflammatory response. This study was done by exposing an non-contact electric field to the U87-MG cell line at three electricity doses (10, 30, and 50 peak-to-peak voltage (Vpp)) and time (24, 48, and 72 hours). TNF-a was examined using western blot after exposure. TNF-a level in the U87-MG cell line raised after 24 hours of exposure, despite not being statistically significant. After 24 hours, TNF-a level gradually decreased over time.
AB - Glioblastoma is a malignant neoplasm of the central nervous system with an abysmal prognosis despite maximum standard therapy. Electro-capacitive cancer therapy (ECCT) is a non-contact electric field therapy popularized in Indonesia. This study aims to explore the effect of ECCT on TNF-a level in glioblastoma cell line in vitro as a representation of inflammatory response. This study was done by exposing an non-contact electric field to the U87-MG cell line at three electricity doses (10, 30, and 50 peak-to-peak voltage (Vpp)) and time (24, 48, and 72 hours). TNF-a was examined using western blot after exposure. TNF-a level in the U87-MG cell line raised after 24 hours of exposure, despite not being statistically significant. After 24 hours, TNF-a level gradually decreased over time.
KW - Electric field therapy
KW - TNF-a
KW - cell line
KW - glioblastoma
KW - inflammation
UR - http://www.scopus.com/inward/record.url?scp=85202585937&partnerID=8YFLogxK
U2 - 10.48309/jmpcr.2025.459934.1266
DO - 10.48309/jmpcr.2025.459934.1266
M3 - Article
AN - SCOPUS:85202585937
SN - 2981-0221
VL - 7
SP - 313
EP - 320
JO - Journal of Medicinal and Pharmaceutical Chemistry Research
JF - Journal of Medicinal and Pharmaceutical Chemistry Research
IS - 2
ER -