Abstract

Glioblastoma is a malignant neoplasm of the central nervous system with an abysmal prognosis despite maximum standard therapy. Electro-capacitive cancer therapy (ECCT) is a non-contact electric field therapy popularized in Indonesia. This study aims to explore the effect of ECCT on TNF-a level in glioblastoma cell line in vitro as a representation of inflammatory response. This study was done by exposing an non-contact electric field to the U87-MG cell line at three electricity doses (10, 30, and 50 peak-to-peak voltage (Vpp)) and time (24, 48, and 72 hours). TNF-a was examined using western blot after exposure. TNF-a level in the U87-MG cell line raised after 24 hours of exposure, despite not being statistically significant. After 24 hours, TNF-a level gradually decreased over time.

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalJournal of Medicinal and Pharmaceutical Chemistry Research
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 2025

Keywords

  • Electric field therapy
  • TNF-a
  • cell line
  • glioblastoma
  • inflammation

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