New isolinariins C, D and E, flavonoid glycosides from Linaria japonica

Retno Widyowati, Sachiko Sugimoto, Yoshi Yamano, Sukardiman, Hideaki Otsuka, Katsuyoshi Matsunami

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Three new flavonoid glycosides named isolinariins C, D and E (1-3), two known flavonoid glycosides (4, 5) and three known flavonoids (6-8) were isolated from the whole plant of Linaria japonica. The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation. Among the isolated compounds, isolinariins C, D and E (1, 2 and 3) showed inhibition toward AGE formation (IC50 values of 34.8, 35.0 and 19.5 μM, respectively). And linariin (4), pectolinarin (5) and luteolin (8) were found to be active against collagenase with IC50 values of 79.4, 78.6 and 40.5 μM, respectively, without significant cytotoxicity at these concentrations.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Issue number5
Publication statusPublished - 2016


  • Advanced glycation end product
  • Collagenase
  • Cytotoxicity
  • Flavonoid glycoside
  • Linaria japonica


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