New isolinariins C, D and E, flavonoid glycosides from Linaria japonica

Retno Widyowati; Sachiko Sugimoto; Yoshi Yamano; Hideaki Otsuka; Katsuyoshi Matsunami

doi:10.1248/cpb.c16-00073

New isolinariins C, D and E, flavonoid glycosides from Linaria japonica

Retno Widyowati, Sachiko Sugimoto, Yoshi Yamano, Sukardiman, Hideaki Otsuka, Katsuyoshi Matsunami

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Three new flavonoid glycosides named isolinariins C, D and E (1-3), two known flavonoid glycosides (4, 5) and three known flavonoids (6-8) were isolated from the whole plant of Linaria japonica. The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation. Among the isolated compounds, isolinariins C, D and E (1, 2 and 3) showed inhibition toward AGE formation (IC₅₀ values of 34.8, 35.0 and 19.5 μM, respectively). And linariin (4), pectolinarin (5) and luteolin (8) were found to be active against collagenase with IC₅₀ values of 79.4, 78.6 and 40.5 μM, respectively, without significant cytotoxicity at these concentrations.

Original language	English
Pages (from-to)	517-521
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	64
Issue number	5
DOIs	https://doi.org/10.1248/cpb.c16-00073
Publication status	Published - 2016

Keywords

Advanced glycation end product
Collagenase
Cytotoxicity
Flavonoid glycoside
Linaria japonica

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/cpb.c16-00073

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title = "New isolinariins C, D and E, flavonoid glycosides from Linaria japonica",

abstract = "Three new flavonoid glycosides named isolinariins C, D and E (1-3), two known flavonoid glycosides (4, 5) and three known flavonoids (6-8) were isolated from the whole plant of Linaria japonica. The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation. Among the isolated compounds, isolinariins C, D and E (1, 2 and 3) showed inhibition toward AGE formation (IC50 values of 34.8, 35.0 and 19.5 μM, respectively). And linariin (4), pectolinarin (5) and luteolin (8) were found to be active against collagenase with IC50 values of 79.4, 78.6 and 40.5 μM, respectively, without significant cytotoxicity at these concentrations.",

keywords = "Advanced glycation end product, Collagenase, Cytotoxicity, Flavonoid glycoside, Linaria japonica",

author = "Retno Widyowati and Sachiko Sugimoto and Yoshi Yamano and Sukardiman and Hideaki Otsuka and Katsuyoshi Matsunami",

note = "Publisher Copyright: {\textcopyright} 2016 The Pharmaceutical Society of Japan.",

year = "2016",

doi = "10.1248/cpb.c16-00073",

language = "English",

volume = "64",

pages = "517--521",

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TY - JOUR

T1 - New isolinariins C, D and E, flavonoid glycosides from Linaria japonica

AU - Widyowati, Retno

AU - Sugimoto, Sachiko

AU - Yamano, Yoshi

AU - Sukardiman,

AU - Otsuka, Hideaki

AU - Matsunami, Katsuyoshi

PY - 2016

Y1 - 2016

N2 - Three new flavonoid glycosides named isolinariins C, D and E (1-3), two known flavonoid glycosides (4, 5) and three known flavonoids (6-8) were isolated from the whole plant of Linaria japonica. The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation. Among the isolated compounds, isolinariins C, D and E (1, 2 and 3) showed inhibition toward AGE formation (IC50 values of 34.8, 35.0 and 19.5 μM, respectively). And linariin (4), pectolinarin (5) and luteolin (8) were found to be active against collagenase with IC50 values of 79.4, 78.6 and 40.5 μM, respectively, without significant cytotoxicity at these concentrations.

AB - Three new flavonoid glycosides named isolinariins C, D and E (1-3), two known flavonoid glycosides (4, 5) and three known flavonoids (6-8) were isolated from the whole plant of Linaria japonica. The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation. Among the isolated compounds, isolinariins C, D and E (1, 2 and 3) showed inhibition toward AGE formation (IC50 values of 34.8, 35.0 and 19.5 μM, respectively). And linariin (4), pectolinarin (5) and luteolin (8) were found to be active against collagenase with IC50 values of 79.4, 78.6 and 40.5 μM, respectively, without significant cytotoxicity at these concentrations.

KW - Advanced glycation end product

KW - Collagenase

KW - Cytotoxicity

KW - Flavonoid glycoside

KW - Linaria japonica

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U2 - 10.1248/cpb.c16-00073

DO - 10.1248/cpb.c16-00073

M3 - Article

C2 - 27150486

AN - SCOPUS:84969581318

SN - 0009-2363

VL - 64

SP - 517

EP - 521

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 5

ER -

New isolinariins C, D and E, flavonoid glycosides from Linaria japonica

Abstract

Keywords

UN SDGs

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