Aim: This research was aimed to determine the potential for treating osteogenesis with a combination of zinc oxide and turmeric (ZOT) rhizome liquid extract. Setting and Design: In vivo, post test-control group design. Material and Methods: The mandibular incisors of Wistar rats were extracted and left untreated or received an application of zinc oxideeugenol (ZOE) 10% or ZOT rhizome liquid extract at various concentrations (10%, 20%, and 40%). The mandible was then subjected to immunohistochemical analysis to detect RUNX2 and alkaline phosphatase (ALP) activity. Statistical Analysis Used: One-way ANOVA and Tukey HSD using SPSS software. Results: All groups demonstrated increasing RUNX2 and ALP activity. ZOT 40% showed the highest activity in all groups on day 3 and day 7, although there were no significant differences with ZOE 10%. Conclusion: A combination of ZOT rhizome liquid extract can induce the osteogenic process in postextraction sockets. The results highlight the need for further investigation of the potential osteogenesis of curcumin in humans.

Original languageEnglish
Pages (from-to)262-268
Number of pages7
JournalThe Journal of Indian Prosthodontic Society
Issue number3
Publication statusPublished - 1 Jul 2021


  • Medicine
  • osteogenesis
  • tooth extraction
  • turmeric
  • zinc oxide


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