New cis-ent-clerodanes from Linaria japonica

Retno Widyowati; Sachiko Sugimoto; Yoshi Yamano; Hideaki Otsuka; Katsuyoshi Matsunami

doi:10.1016/j.phytol.2015.09.002

New cis-ent-clerodanes from Linaria japonica

Retno Widyowati, Sachiko Sugimoto, Yoshi Yamano, Sukardiman, Hideaki Otsuka, Katsuyoshi Matsunami

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Five new cis-ent-clerodanes, linarenones A-E (1-5) and two known compounds (6 and 7) were isolated from whole plant of Linaria japonica. The structures of these compounds were determined by various spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR). The absolute configuration of five new diterpenoids was confirmed by circular dichroism (CD) analysis and chemical conversion. Cytotoxicity of the isolated compounds against A549 cell lines and Leishmania major were evaluated. The new cis-ent-clerodane 3 was found to be moderately active against A549 cell lines, and new cis-ent-clerodanes 1, 6 and desacetyl-linarienone (7) were active against L. major.

Original language	English
Article number	1029
Pages (from-to)	56-62
Number of pages	7
Journal	Phytochemistry Letters
Volume	14
DOIs	https://doi.org/10.1016/j.phytol.2015.09.002
Publication status	Published - 1 Dec 2015

Keywords

Cytotoxicity
Leishmania
Linarenone
Linaria japonica
cis-ent-Clerodane

Access to Document

10.1016/j.phytol.2015.09.002

Cite this

@article{460935fb31cb45d3ae20fda6e0341070,

title = "New cis-ent-clerodanes from Linaria japonica",

abstract = "Five new cis-ent-clerodanes, linarenones A-E (1-5) and two known compounds (6 and 7) were isolated from whole plant of Linaria japonica. The structures of these compounds were determined by various spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR). The absolute configuration of five new diterpenoids was confirmed by circular dichroism (CD) analysis and chemical conversion. Cytotoxicity of the isolated compounds against A549 cell lines and Leishmania major were evaluated. The new cis-ent-clerodane 3 was found to be moderately active against A549 cell lines, and new cis-ent-clerodanes 1, 6 and desacetyl-linarienone (7) were active against L. major.",

keywords = "Cytotoxicity, Leishmania, Linarenone, Linaria japonica, cis-ent-Clerodane",

author = "Retno Widyowati and Sachiko Sugimoto and Yoshi Yamano and Sukardiman and Hideaki Otsuka and Katsuyoshi Matsunami",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.phytol.2015.09.002",

language = "English",

volume = "14",

pages = "56--62",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - New cis-ent-clerodanes from Linaria japonica

AU - Widyowati, Retno

AU - Sugimoto, Sachiko

AU - Yamano, Yoshi

AU - Sukardiman,

AU - Otsuka, Hideaki

AU - Matsunami, Katsuyoshi

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Five new cis-ent-clerodanes, linarenones A-E (1-5) and two known compounds (6 and 7) were isolated from whole plant of Linaria japonica. The structures of these compounds were determined by various spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR). The absolute configuration of five new diterpenoids was confirmed by circular dichroism (CD) analysis and chemical conversion. Cytotoxicity of the isolated compounds against A549 cell lines and Leishmania major were evaluated. The new cis-ent-clerodane 3 was found to be moderately active against A549 cell lines, and new cis-ent-clerodanes 1, 6 and desacetyl-linarienone (7) were active against L. major.

AB - Five new cis-ent-clerodanes, linarenones A-E (1-5) and two known compounds (6 and 7) were isolated from whole plant of Linaria japonica. The structures of these compounds were determined by various spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR). The absolute configuration of five new diterpenoids was confirmed by circular dichroism (CD) analysis and chemical conversion. Cytotoxicity of the isolated compounds against A549 cell lines and Leishmania major were evaluated. The new cis-ent-clerodane 3 was found to be moderately active against A549 cell lines, and new cis-ent-clerodanes 1, 6 and desacetyl-linarienone (7) were active against L. major.

KW - Cytotoxicity

KW - Leishmania

KW - Linarenone

KW - Linaria japonica

KW - cis-ent-Clerodane

UR - http://www.scopus.com/inward/record.url?scp=84942080987&partnerID=8YFLogxK

U2 - 10.1016/j.phytol.2015.09.002

DO - 10.1016/j.phytol.2015.09.002

M3 - Article

AN - SCOPUS:84942080987

SN - 1874-3900

VL - 14

SP - 56

EP - 62

JO - Phytochemistry Letters

JF - Phytochemistry Letters

M1 - 1029

ER -

New cis-ent-clerodanes from Linaria japonica

Abstract

Keywords

Access to Document

Fingerprint

Cite this