New arylalkanones from Horsfieldia macrobotrys, effective antidiabetic agents concomitantly inhibiting α-glucosidase and free radicals

Rico Ramadhan, Preecha Phuwapraisirisan

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

In search of effective antidiabetic agents having therapeutic effect by inhibiting α-glucosidase and preventive effect by scavenging free radicals, Horsfieldia macrobotrys showed promising bioactivity required for the proposed criteria. Bioassay-guided isolation of the stem bark extract resulted in two new arylalkanones named horsfieldone A (1) and maingayone D (2), together with a new flavanone C-glucoside named 8-C-β-d-glucopyranosylpinocembrin (3). Their structures and stereochemistry were determined by spectroscopic techniques as well as Mosher's method. Of isolated compounds, maingayone D (2) was the most potent inhibitors against both α-glucosidases and free radicals. The presence of additional phenolic moieties in 2 clearly indicated their critical roles in inhibitory effects. Further investigation on mechanism underlying α-glucosidase inhibition indicated that maingayone D (2) could retard the enzyme function by both competitive and noncompetitive manners.

Original languageEnglish
Pages (from-to)4529-4533
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number20
DOIs
Publication statusPublished - 15 Oct 2015
Externally publishedYes

Keywords

  • Antioxidant
  • Arylalkanone
  • Diabetes
  • Glucosidase
  • Horsfieldia macrobotrys
  • Myristica motley

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