TY - JOUR
T1 - Negative correlation between serum brain-derived neurotrophic factor levels and obesity predictor markers and inflammation levels in females with obesity
AU - Raharjo, Slamet
AU - Pranoto, Adi
AU - Rejeki, Purwo Sri
AU - Harisman, A. S.M.
AU - Pamungkas, Yualita Putri
AU - Andiana, Olivia
N1 - Publisher Copyright:
© 2021 Slamet Raharjo, Adi Pranoto, Purwo Sri Rejeki, A. S. M. Harisman, Yualita Putri Pamungkas, Olivia Andiana.
PY - 2021/12/26
Y1 - 2021/12/26
N2 - BACKGROUND: Obesity has been widely associated with structural and functional changes in brain, whereas inflammation is one of the potential mechanisms involved in these changes. AIM: This study aims to prove the relationship between serum brain-derived neurotrophic factor (BDNF) levels and obesity predictor markers (body mass index [BMI] and waist to hip ratio [WHR]) and inflammation (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]) levels of in females with obesity. METHODS: This study used a cross-sectional study method using 33 female with obesity aged 19–23 years, BMI >27.5 kg/m2, normal blood pressure, normal resting heart rate, normal hemoglobin, and fasting blood glucose ≤100 mg/dL. The examination of serum BDNF, IL-6, and TNF-α levels using the Enzyme-Linked Immunosorbent Assay method. The data were analyzed using Pearson product-moment test with a significant levels p < 0.05. RESULTS: The results indicated that there is a negative correlation between serum BDNF levels and BMI (r = –0.759; p < 0.001), WHR (r = –0.675; p < 0.001), IL-6 levels (r = –0.530; p < 0.001), and TNF-α levels (r = –0.561; p < 0.001). CONCLUSION: Based on the results of the study, there is a negative correlation between serum BDNF levels and BMI, WHR, and inflammation (IL-6 and TNF-α) levels in females with obesity. Further studies are needed to confirm the present findings.
AB - BACKGROUND: Obesity has been widely associated with structural and functional changes in brain, whereas inflammation is one of the potential mechanisms involved in these changes. AIM: This study aims to prove the relationship between serum brain-derived neurotrophic factor (BDNF) levels and obesity predictor markers (body mass index [BMI] and waist to hip ratio [WHR]) and inflammation (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]) levels of in females with obesity. METHODS: This study used a cross-sectional study method using 33 female with obesity aged 19–23 years, BMI >27.5 kg/m2, normal blood pressure, normal resting heart rate, normal hemoglobin, and fasting blood glucose ≤100 mg/dL. The examination of serum BDNF, IL-6, and TNF-α levels using the Enzyme-Linked Immunosorbent Assay method. The data were analyzed using Pearson product-moment test with a significant levels p < 0.05. RESULTS: The results indicated that there is a negative correlation between serum BDNF levels and BMI (r = –0.759; p < 0.001), WHR (r = –0.675; p < 0.001), IL-6 levels (r = –0.530; p < 0.001), and TNF-α levels (r = –0.561; p < 0.001). CONCLUSION: Based on the results of the study, there is a negative correlation between serum BDNF levels and BMI, WHR, and inflammation (IL-6 and TNF-α) levels in females with obesity. Further studies are needed to confirm the present findings.
KW - Body mass index
KW - Brain-derived neurotrophic factor
KW - Interleukin-6
KW - Obesity
KW - Tumor necrosis factor-α
KW - Waist hip ratio
UR - http://www.scopus.com/inward/record.url?scp=85116550863&partnerID=8YFLogxK
U2 - 10.3889/oamjms.2021.6840
DO - 10.3889/oamjms.2021.6840
M3 - Article
AN - SCOPUS:85116550863
SN - 1857-5749
VL - 9
SP - 1021
EP - 1026
JO - Open Access Macedonian Journal of Medical Sciences
JF - Open Access Macedonian Journal of Medical Sciences
ER -