Naproxen release from carbon dot coated magnetite nanohybrid as versatile theranostics for HeLa cancer cells

Mochamad Z. Fahmi, Nurlailiatul Machmudah, Putri Indrawasih, Aswandi Wibrianto, Musbahu A. Ahmad, Satya C.W. Sakti, Jia Yaw Chang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Nanohybrid magnetite carbon dots (Fe3O4@CDs) were successfully synthesized to improve their applicability in multi-response bioimaging. The nanohybrid was prepared via pyrolysis and further loaded with naproxen (NAP) to promote drug delivery features. The characterization of the synthesized Fe3O4@CDs demonstrated the existence of Fe3O4 crystals by matching with JCPDS 75-0033 and its narrow size distribution at 11.30 nm; further, FTIR spectra confirmed the presence of Fe-O groups, C-O stretching, C-H sp2, and C-O bending, along with dual-active fluorescence and magnetic responses. The nanohybrids also exhibit particular properties such as a maximum wavelength of 230.5 nm, maximum emission in the 320-420 nm range, and slight superparamagnetic reduction (Fe3O4: 0.93620 emu per g; Fe3O4@CDs: 0.64784 emu per g). The cytotoxicity assessment of the nanohybrid revealed an excellent half-maximal inhibitory concentration (IC50) of 17 671.5 ± 1742.6 μg mL−1. Then, the incorporation of NAP decreased the cell viability to below 10%. The kinetic release properties of NAP are also confirmed as pH-dependent, and they follow the Korsmeyer-Peppas kinetics model. These results indicated that the proposed Fe3O4@CDs can be used as a new model for theranostic treatment.

Original languageEnglish
Pages (from-to)32328-32337
Number of pages10
JournalRSC Advances
Volume12
Issue number50
DOIs
Publication statusPublished - 11 Nov 2022

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