Nanoparticle formulation of ZnO: TiO2 as sunscreen cream for Cutaneous Lupus Erythematosus (CLE) patients

Cutaneous Lupus Erythematosus (CLE) is a form of lupus that affects the skin and is highly sensitive to ultraviolet (UV) light. UV-B. in particular. can trigger inflammation and apoptosis in CLE patients. making a sunscreen with effective UVB protection crucial. This study evaluates the effectiveness of zinc oxide (ZnO) and titanium dioxide (TiO2) nanoparticles in sunscreen. ZnO and TiO2 nanoparticles were prepared using the High Energy Milling method. resulting in particle sizes of 7.77 nm and 4.44 nm. respectively. The creams containing these nanoparticles were tested for physical stability and UV protection. Results showed that the creams were physically stable and provided good UV protection. with ZnO and TiO2 nanoparticles making up 12.60% of the total cream ingredients. resulting in the highest SPF (Sun Protection Factor) value of 62.0 ± 1.37.