Nanohydroxyapatite-Chitosan Hydrogel Scaffold with Platelet Rich Fibrin and Buccal Fat Pad derived Stem Cell for Aggressive Periodontitis Treatment: A Narrative Review

Gustiadi Saputra, Alexander Patera Nugraha, Theresia Indah Budhy, Fransisca Shancti Rosari, Nur Aini Indah Lestari, Alifiya Afita Sari, Afiqah Gheasani, Theodora Valensia, Nastiti Faradilla Ramadhani, Tengku Natasha Eleena Binti Tengku Ahmad Noor, Albertus Putera Nugraha, Andreas Pratama Nugraha, Agung Sosiawan

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Periodontal disease is oral health problem which attacks 20-50% of the global population. In Indonesia, 60% population suffers periodontal disease and become the second most common disease in the oral cavity. Aggressive periodontitis (AP) is one of periodontal disease, mainly attacks individual under 30 years-old, with rapid alveolar bone destruction. Bone graft implantation surgery is the current treatment for AP, but it is invasive and high risk infection. Nanohydroxyapatite-chitosan (nHPA-CS) hydrogel injectable scaffold is non-invasive treatment that contains bone mineral hydroxyapatite that derived from bovine bone and chitosan (CS) biopolymer with low immunogenicity. Platelet-Rich-Fibrin (PRF) contains huge amount growth factor which is biodegradable to human body. Buccal-Fat-Pad Stem-Cell (BFPSC) was chosen because it is easy to harvest and able to differentiate into mesenchymal lineage tissue. The aim of this narrative review is to describe the potential combination of nanohydroxyapatite-chitosan hydrogel scaffold, platelet-rich-fibrin, and buccal-fat-pad stem-cells for regenerating alveolar bone in aggressive-periodontitis patients. Data was obtained by literature study scientific research articles. In patients with AP, BFPSC can differentiate into osteoblast to improve osteogenesis, nHPA-CS scaffold creates host like tissue microenvironment to stimulate osteoinduction and osteoconduction activity of BFPSC, while PRF stimulates osteogenic differentiation and proliferation of BFPSC with insulin growth-factor, platelets derived growth-factor, transforming growth-factor, fibroblast growth-factor, vascular endothelial growth-factor. this combination increasing runt-related transcription-factor2, osterix, bone alkaline phosphatase, and controls pro-inflammatory cytokines such as interleukin-1beta (IL-1b) and tumor necrosis factor-alpha (TNF-a) so it can enhance bone regeneration and avoid bone destruction. The combination of nHPA-CS, PRF, BFPSC has the potential for alveolar bone regeneration in Aggressive-Periodontitis patients.

Original languageEnglish
Pages (from-to)5903-5908
Number of pages6
JournalResearch Journal of Pharmacy and Technology
Issue number12
Publication statusPublished - Dec 2022


  • Nanohydroxyapatite-chitosan hydrogel
  • buccal fat pad mesenchymal stem cells
  • infectious disease
  • medicine
  • platelet rich fibrin


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