Nanohybrid carbon nanodots-CuFe2O4 as selectively magnetofluorescent agent on tumor cells

Mochamad Z. Fahmi, Denika L.N. Wibowo, Yu yu Aung, Nindayu Indrasari, Yatim L. Nikmah, Satya C.W. Sakti, Irzaman Irzaman, Che A.C. Abdullah

Research output: Contribution to journalArticlepeer-review


The magnetic material with carbon nanodots as magnetofluorescent multi-agents was an effective way to determine cellular information in clinical diagnosis systems. However, exploring hyaluronic acid (HA) on magnetofluorescent is limited in combining with CuFe2O4. The present study reports a new design contrast agent as a hybrid carbon nanodots (CNDs–CuFe2O4–HA) by combining the fluorescence carbon nanodots (CNDs) and copper ferrite (CuFe2O4) nanoparticles capsulated with HA. The as-prepared nanohybrid confirmed the unique properties through some important analytical techniques. The photoluminescence data showed an average diameter of the nanohybrid of about 104 nm and exhibited blue emission (λ em = 420 nm). The hybrid also showed the superparamagnetic behavior and saturated magnetization (M s) value of 0.63 emug−1, which increased the positive contrast on T1-weight relaxation of MRI as well as its specific targeting to the tumor assessed by confocal microscopy. The effective nanohybrid particles also described remarkable fluorescence and non-toxicity features that are useful for clinical diagnosis information. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)3416-3428
Number of pages13
JournalJournal of Materials Research
Issue number13
Publication statusPublished - 14 Jul 2023


  • Cancer
  • Carbon nanodots
  • CuFeO
  • Hyaluronic acid
  • Magnetofluorescent


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