Objective: This study aims to investigate the protective effect of nanocurcumin on lipid peroxidation of rat ovarian granulosa cells induced by lead acetate (Pb). Methods: A total of 45 mice were divided into a negative control group (C-) receiving corn oil, a positive control group (C+) receiving corn oil and lead acetate (Pb) 40 mg/kg bw/day, experimental group 1 (E1), experimental group 2 (E2), experimental group 3 (E3) receiving 50, 100 and 200 mg/kg/day nanocurcumin dissolved in corn oil and lead acetate (Pb) 40 mg/kg bw/day. The treatment was given orally and the treatment time was daily at 08.00 AM for 26 days. Ovaries were removed for immunohistochemical analysis of MDA expression. Result: The positive control group had the highest MDA expression of ovarian granulosa cells (94.2 ± 10.5) and was significantly different (p <0.05) from negative control group (1.5 ± 1.4), experimental group 1 (17.4 ± 10.5), experimental group 2 (11.4 ± 8.5) and experimental group 3 (7.2 ± 4.0). Conclusion: Nanocurcumin as a protective oxidative stress on ovarian granulosa cells due to exposure to lead acetate, by protecting lipid peroxidation.

Original languageEnglish
Pages (from-to)764-769
Number of pages6
JournalIndian Journal of Forensic Medicine and Toxicology
Issue number4
Publication statusPublished - 1 Oct 2020


  • Lead acetate
  • Malondialdehyde (MDA)
  • Nanocurcumin


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