TY - JOUR
T1 - Multivalent dengue vaccines and its cellular immune response in New Zealand white rabbit
AU - Yustinasari, Lita Rakhma
AU - Ernawati, Rahayu
AU - Rantam, Fedik Abdul
AU - Widodo, Agus
N1 - Publisher Copyright:
© 2019 Indian Veterinary Assocaition. All rights reserved.
PY - 2019
Y1 - 2019
N2 - A study was planned to investigate the role of multivalent dengue vaccines in rabbit cellular immune response. Eighteen rabbits were divided into three groups. P0 was injected with PBS as a control, P1 was vaccinated with 0.5 cc, and P2 was vaccinated with 0.3 cc and booster was done on day 14. Blood sample was collected on days 0, 7, 14, 21, and 28 for analysis of peripheral blood mononuclear cells (PBMCs) by immunofluorescence.Rabbits vaccinated with multivalent dengue vaccines displayed significantly higher numbers of TLR, CD4+ and CD8+ T cells (p<0.05) compared with the control. It was concluded that multivalent dengue vaccines could increase cellular immune response against DENV in rabbit.
AB - A study was planned to investigate the role of multivalent dengue vaccines in rabbit cellular immune response. Eighteen rabbits were divided into three groups. P0 was injected with PBS as a control, P1 was vaccinated with 0.5 cc, and P2 was vaccinated with 0.3 cc and booster was done on day 14. Blood sample was collected on days 0, 7, 14, 21, and 28 for analysis of peripheral blood mononuclear cells (PBMCs) by immunofluorescence.Rabbits vaccinated with multivalent dengue vaccines displayed significantly higher numbers of TLR, CD4+ and CD8+ T cells (p<0.05) compared with the control. It was concluded that multivalent dengue vaccines could increase cellular immune response against DENV in rabbit.
KW - Cellular immune response
KW - Multivalent dengue vaccine
KW - T cells
KW - TLR
UR - http://www.scopus.com/inward/record.url?scp=85071683353&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85071683353
SN - 0019-6479
VL - 96
SP - 37
EP - 38
JO - Indian Veterinary Journal
JF - Indian Veterinary Journal
IS - 6
ER -
