A study was planned to investigate the role of multivalent dengue vaccines in rabbit cellular immune response. Eighteen rabbits were divided into three groups. P0 was injected with PBS as a control, P1 was vaccinated with 0.5 cc, and P2 was vaccinated with 0.3 cc and booster was done on day 14. Blood sample was collected on days 0, 7, 14, 21, and 28 for analysis of peripheral blood mononuclear cells (PBMCs) by immunofluorescence.Rabbits vaccinated with multivalent dengue vaccines displayed significantly higher numbers of TLR, CD4+ and CD8+ T cells (p<0.05) compared with the control. It was concluded that multivalent dengue vaccines could increase cellular immune response against DENV in rabbit.

Original languageEnglish
Pages (from-to)37-38
Number of pages2
JournalIndian Veterinary Journal
Issue number6
Publication statusPublished - 2019


  • Cellular immune response
  • Multivalent dengue vaccine
  • T cells
  • TLR


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