Objective: Diabetic foot ulcers (DFUs) are a diabetes mellitus (DM) complication with a high mortality rate. This research aimed to demonstrate a mortality prediction model in patients with DFUs. Material and Methods: This research conducted a case-control study based on secondary data from the medical records of DFU patients in Dr. Soetomo General Hospital, a tertiary referral hospital in Surabaya, Indonesia, between 2016-2018. The association between various risk factors and mortality was analyzed using bivariate and multivariate analyses to make a mortality prediction model. Results: 358 subjects (179 cases and 179 controls) were included in the final analysis. Septic shock was the major cause of DFU death. Both bivariate and multivariate analyses determined that 5 independent variables were associated with the mortality in DFU patients, namely albumin level (p-value<0.001 OR 16.52 CI 95% 3.42–79.86), sepsis (p-value<0.001 OR 23.47 CI 95% 5.80–26.85), renal function impairment (p-value<0.001 OR 3.41 CI 95% 1.87–6.21), cardiovascular complications (p-value<0.001 OR 2.93 CI 95% 1.64–5.25), and the severity level of the ulcers using Wagner’s classification (p-value<0.001 OR 6.80 CI 95% 3.77–12.27). The mortality prediction model showed a maximum score of 7, indicating a 98.4% mortality risk. Conclusion: Low albumin level, sepsis, renal function impairment, cardiovascular complications, and Wagner’s severity level IV–V of the DF ulcers were the predictors of mortality in DFUs.

Original languageEnglish
Article numbere2022894
JournalJournal of Health Science and Medical Research
Issue number1
Publication statusPublished - 1 Jan 2023


  • diabetes mellitus
  • diabetic foot ulcer
  • mortality
  • risk factors


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