Morphology characterization and biocompatibility study of PLLA (Poly-L-Llactid-Acid) coating chitosan as stent for coronary heart disease

Prihartini Widiyanti, Adanti W. Paramadini, Hajria Jabbar, Inas Fatimah, Fadila N.K. Nisak, Rahma A. Puspitasari

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

Cardiovascular disease is a global disease with high urgency. In the severe case of coronary heart disease while a blockage in the coronary arteries reach 75% or more, the patient required stent implantation. Stents are made of metal which has many limitations that can lead to blood clots and stent incompatibility toward the size of the blood vessels. There is a metal stent replacement solution that made from polymer material which is biocompatible. PLLA also has biocompatibility and good mechanical strength. PLLA stent will be coated with chitosan as a candidate for drug-coated stents which is able to work as a drug carrier. The aim of this study is to know the morphology information and biocompability status of PLLA coating chitosan as candidate of heart stent. Morphological results using SEM showed a smooth surface structure which reinforced clinical standard of stent material. Results of cytotoxicity test by MTT Assay method showed that the result of four samples in this experiment living cells is reached 90% which is non toxic and safe to use in the human body. %). The conclusion of this study is PLLA is polymer has potency to be used as stent material.

Original languageEnglish
Title of host publication5th International Conference and Workshop on Basic and Applied Sciences, ICOWOBAS 2015
EditorsMoh. Yasin, Sulaiman W. Harun
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735413641
DOIs
Publication statusPublished - 15 Mar 2016
Event5th International Conference and Workshop on Basic and Applied Sciences, ICOWOBAS 2015 - Surabaya, Indonesia
Duration: 16 Oct 201517 Oct 2015

Publication series

NameAIP Conference Proceedings
Volume1718
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Conference and Workshop on Basic and Applied Sciences, ICOWOBAS 2015
Country/TerritoryIndonesia
CitySurabaya
Period16/10/1517/10/15

Keywords

  • Chitosan
  • MTT Assay
  • Poly-L-Lactid-Acid
  • SEM
  • Stent

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