Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women

Purwo Sri Rejeki, Pradika Gita Baskara, Lilik Herawati, Adi Pranoto, Hayuris Kinandita Setiawan, Ronny Lesmana, Shariff Halim

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Objectives: Positive energy homeostasis due to overnutrition and a sedentary lifestyle triggers obesity. Obesity has a close relationship with elevated levels of betatrophin and may increase the risk of developing metabolic syndrome. Therefore, lifestyle modification through a nonpharmacological approach based on physical exercise is the right strategy in lowering betatrophin levels. This study aimed to analyze the effect of moderate-intensity interval and continuous exercises on decreased betatrophin levels and the association between betatrophin levels and obesity markers in women. Methods: A total of 30 women aged 20-24 years old were randomly divided into three groups. Measurement of betatrophin levels using Enzyme-Linked Immunosorbent Assay (ELISA). Data analysis techniques used were one-way ANOVA and parametric linear correlation. Results: The results showed that the average levels of betatrophin pre-exercise were 200.40 ± 11.03 pg/mL at CON, 203.07 ± 42.48 pg/mL at MIE, 196.62 ± 21.29 pg/mL at MCE, and p=0.978. Average levels of betatrophin post-exercise were 226.65 ± 18.96 pg/mL at CON, 109.31 ± 11.23 pg/mL at MIE, 52.38 ± 8.18 pg/mL at MCE, and p=0.000. Pre-exercise betatrophin levels were positively correlated with age, BMI, FM, WHR, FBG, and PBF (p≤0.001). Conclusions: Our study showed that betatrophin levels are decreased by 10 min post-MIE and post-MCE. However, moderate-intensity continuous exercise is more effective in lowering betatrophin levels than moderate-intensity interval exercise. In addition, pre-exercise betatrophin levels also have a positive correlation with obesity markers.

Original languageEnglish
Pages (from-to)769-777
Number of pages9
JournalJournal of Basic and Clinical Physiology and Pharmacology
Issue number6
Publication statusPublished - 1 Nov 2022


  • betatrophin
  • moderate-intensity exercise
  • myokine
  • obesity


Dive into the research topics of 'Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women'. Together they form a unique fingerprint.

Cite this