TY - JOUR
T1 - MnFe2O4 nanoparticles/cellulose acetate composite nanofiber for controllable release of naproxen
AU - Fahmi, Mochamad Zakki
AU - Prasetya, Roch Adi
AU - Dzikri, Muhammad Fathan
AU - Sakti, Satya Candra Wibawa
AU - Yuliarto, Brian
AU - Irzaman,
AU - Ferdiansjah,
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Nanofibers have been demonstrated to be highly effective for drug delivery applications. Although magnetic nanoparticles (MNPs) have been potentially added to nanofibers for improved drug release stimulation, the effect has been limited. In this study, a magnetic nanofiber membrane composed of cellulose acetate (CA), collagen (COL), and MnFe2O4 MNPs was prepared by electrospinning. Naproxen (NAP) drug was deposited on the nanofibers, and the drug release mechanism and effect of the MNPs on the stimulated NAP release were investigated. The electrical conductivity of the dope solution strongly affected the nanofiber characteristics. Moreover, the MTT cytotoxicity assay proved that CA-COL, CA-COL-NAP, and CA-COL-NAP-MNP nanofibers had low toxicity, as the cell viability was >80%. The NAP release mechanism was determined using zero-order, first-order, Higuchi, and Korsmeyer-Peppas kinetics models. According to the dissolution results, for all nanofibers, the NAP release followed the Korsmeyer-Peppas kinetics model, and the transport mechanism was Fickian diffusion. A high MNP concentration and neutral pH condition were conducive to NAP release.
AB - Nanofibers have been demonstrated to be highly effective for drug delivery applications. Although magnetic nanoparticles (MNPs) have been potentially added to nanofibers for improved drug release stimulation, the effect has been limited. In this study, a magnetic nanofiber membrane composed of cellulose acetate (CA), collagen (COL), and MnFe2O4 MNPs was prepared by electrospinning. Naproxen (NAP) drug was deposited on the nanofibers, and the drug release mechanism and effect of the MNPs on the stimulated NAP release were investigated. The electrical conductivity of the dope solution strongly affected the nanofiber characteristics. Moreover, the MTT cytotoxicity assay proved that CA-COL, CA-COL-NAP, and CA-COL-NAP-MNP nanofibers had low toxicity, as the cell viability was >80%. The NAP release mechanism was determined using zero-order, first-order, Higuchi, and Korsmeyer-Peppas kinetics models. According to the dissolution results, for all nanofibers, the NAP release followed the Korsmeyer-Peppas kinetics model, and the transport mechanism was Fickian diffusion. A high MNP concentration and neutral pH condition were conducive to NAP release.
KW - Cellulose acetate
KW - Kinetic release
KW - MnFeO nanoparticles
KW - Nanofiber
KW - Naproxen
UR - http://www.scopus.com/inward/record.url?scp=85083324072&partnerID=8YFLogxK
U2 - 10.1016/j.matchemphys.2020.123055
DO - 10.1016/j.matchemphys.2020.123055
M3 - Article
AN - SCOPUS:85083324072
SN - 0254-0584
VL - 250
JO - Materials Chemistry and Physics
JF - Materials Chemistry and Physics
M1 - 123055
ER -