TY - JOUR
T1 - Mixed Polymethylmethacrylate and Hydroxyapatite as a Candidate of Synthetic Graft Materials for Cleft Palate
AU - Saskianti, Tania
AU - Novianti, Aisyah
AU - Sahar, Diina
AU - Nugraha, Alexander Patera
AU - Putri, Tansza Setiana
AU - Kanawa, Masami
AU - Puteri, Mega Moeharyono
AU - Dewi, Ardianti Maartrina
AU - Ernawati, Diah Savitri
N1 - Funding Information:
Research reported in this publication was supported by the Penelitian Dasar Unggulan Perguruan Tinggi (PDUPT) Research Grant 2021 (No: 327/UN3.15/PT/2021) from the Ministry of Research, Technology, and Higher Education, Indonesian Government.
Funding Information:
Research reported in this publication was supported by the Penelitian Dasar Unggulan Perguruan Tinggi (PDUPT) Research Grant 2021 (No: 327/UN3.15/PT/2021) from the Ministry of Research, Technology, and Higher Education, Indonesian oGvernment.
Publisher Copyright:
© 2022. Journal of International Dental and Medical Research. All Rights Reserved.
PY - 2022
Y1 - 2022
N2 - This research aimed to investigate scaffolds of mixed polymethylmethacrylate (PMMA) and hydroxyapatite (HA) that can be considered as a candidate of synthetic graft materials for cleft palate. Polymethylmethacrylate-hydroxyapatite (PMMA-HA) scaffold was done by weighing PMMA granules and HA powder for a 20:80, 30:70 and 40:60 ratio, that mixed and moulded in 5 mm of diameter and 10 mm of height, then freeze dried before being analyzed by X-Ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), Scanning electron microscope (SEM) and Energy dispersive X-ray (EDX) instruments. XRD analysis in 20:80, 30:70 and 40:60 ratio has a peak that represents HA and an amorphous peak that represents PMMA, with the best ratio is 30:70.FTIR analysis showed the existence of HA functional groups namely phosphate (PO4 3-), calcium carbonate (CO3 2-), and hydroxyl (OH-) in all three samples, with 20:80 ratio as the optimal composition. SEM observation showed visible interconnected pores and roughness, also various pore sizes that averaged by 278.71μm; 312.3μm; 332.8μm, and 1.267μm; 1.716μm; 1.951μm, that showed by 50x and 5000x magnification, with 20:80 ratio as the ideal environment. EDX analysis showed Calsium (Ca), Oxygen (O), Phosphate (P), Silicate (Si), and Aluminium (Al) contained in the PMMA-HA sample, with 20:80 ratio as the highest potention to osteoblast regeneration. PMMA-HA scaffold with 20:80 ratio considered as the best ratio to be a candidate of synthetic graft materials for cleft palate.
AB - This research aimed to investigate scaffolds of mixed polymethylmethacrylate (PMMA) and hydroxyapatite (HA) that can be considered as a candidate of synthetic graft materials for cleft palate. Polymethylmethacrylate-hydroxyapatite (PMMA-HA) scaffold was done by weighing PMMA granules and HA powder for a 20:80, 30:70 and 40:60 ratio, that mixed and moulded in 5 mm of diameter and 10 mm of height, then freeze dried before being analyzed by X-Ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), Scanning electron microscope (SEM) and Energy dispersive X-ray (EDX) instruments. XRD analysis in 20:80, 30:70 and 40:60 ratio has a peak that represents HA and an amorphous peak that represents PMMA, with the best ratio is 30:70.FTIR analysis showed the existence of HA functional groups namely phosphate (PO4 3-), calcium carbonate (CO3 2-), and hydroxyl (OH-) in all three samples, with 20:80 ratio as the optimal composition. SEM observation showed visible interconnected pores and roughness, also various pore sizes that averaged by 278.71μm; 312.3μm; 332.8μm, and 1.267μm; 1.716μm; 1.951μm, that showed by 50x and 5000x magnification, with 20:80 ratio as the ideal environment. EDX analysis showed Calsium (Ca), Oxygen (O), Phosphate (P), Silicate (Si), and Aluminium (Al) contained in the PMMA-HA sample, with 20:80 ratio as the highest potention to osteoblast regeneration. PMMA-HA scaffold with 20:80 ratio considered as the best ratio to be a candidate of synthetic graft materials for cleft palate.
KW - Edx
KW - Ftir
KW - Good health and well-being
KW - Scaffold
KW - Sem
KW - Xrd
UR - http://www.scopus.com/inward/record.url?scp=85133758046&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85133758046
SN - 1309-100X
VL - 15
SP - 538
EP - 543
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 2
ER -