Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

Elisa Giovannetti; Dewa G. Ugrasena; Eddy Supriyadi; Laura Vroling; Antonino Azzarello; Desiree de Lange; Godefridus J. Peters; Anjo J.P. Veerman; Jacqueline Cloos

doi:10.1016/j.leukres.2007.02.011

Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

Elisa Giovannetti, Dewa G. Ugrasena, Eddy Supriyadi, Laura Vroling, Antonino Azzarello, Desiree de Lange, Godefridus J. Peters, Anjo J.P. Veerman, Jacqueline Cloos

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Genetic variations in the polymorphic tandem repeat sequence of the enhancer region of the thymidylate synthase promoter (TSER), as well as in methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, influence methotrexate sensitivity. We studied these polymorphisms in children with acute lymphoblastic leukaemia (ALL) and in subjects without malignancy in Indonesia and Holland. The frequencies of TT and CT genotypes were two-fold higher in Dutch children. The TSER 3R/3R repeat was three-fold more frequent in the Indonesian children, while the 2R/2R repeat was only 1% compared to 21% in the Dutch children. No differences of these polymorphisms were found between ALL cells and normal blood cells, indicating an ethnic rather than leukemic origin. These results may have implications for treatment of Indonesian children with ALL.

Original language	English
Pages (from-to)	19-24
Number of pages	6
Journal	Leukemia Research
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2007.02.011
Publication status	Published - Jan 2008

Keywords

Acute lymphoblastoid leukemia
Indonesia
MTHFR C677T
Methotrexate
Paediatric patients
TSER 2R/3R

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2007.02.011

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Giovannetti, E., Ugrasena, D. G., Supriyadi, E., Vroling, L., Azzarello, A., de Lange, D., Peters, G. J., Veerman, A. J. P., & Cloos, J. (2008). Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia. Leukemia Research, 32(1), 19-24. https://doi.org/10.1016/j.leukres.2007.02.011

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title = "Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia",

abstract = "Genetic variations in the polymorphic tandem repeat sequence of the enhancer region of the thymidylate synthase promoter (TSER), as well as in methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, influence methotrexate sensitivity. We studied these polymorphisms in children with acute lymphoblastic leukaemia (ALL) and in subjects without malignancy in Indonesia and Holland. The frequencies of TT and CT genotypes were two-fold higher in Dutch children. The TSER 3R/3R repeat was three-fold more frequent in the Indonesian children, while the 2R/2R repeat was only 1% compared to 21% in the Dutch children. No differences of these polymorphisms were found between ALL cells and normal blood cells, indicating an ethnic rather than leukemic origin. These results may have implications for treatment of Indonesian children with ALL.",

keywords = "Acute lymphoblastoid leukemia, Indonesia, MTHFR C677T, Methotrexate, Paediatric patients, TSER 2R/3R",

author = "Elisa Giovannetti and Ugrasena, {Dewa G.} and Eddy Supriyadi and Laura Vroling and Antonino Azzarello and {de Lange}, Desiree and Peters, {Godefridus J.} and Veerman, {Anjo J.P.} and Jacqueline Cloos",

note = "Funding Information: This study was supported by a grant (KWF-IN-2006-22) from the Dutch Cancer Society. ",

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Giovannetti, E, Ugrasena, DG, Supriyadi, E, Vroling, L, Azzarello, A, de Lange, D, Peters, GJ, Veerman, AJP & Cloos, J 2008, 'Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia', Leukemia Research, vol. 32, no. 1, pp. 19-24. https://doi.org/10.1016/j.leukres.2007.02.011

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T1 - Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

AU - Giovannetti, Elisa

AU - Ugrasena, Dewa G.

AU - Supriyadi, Eddy

AU - Vroling, Laura

AU - Azzarello, Antonino

AU - de Lange, Desiree

AU - Peters, Godefridus J.

AU - Veerman, Anjo J.P.

AU - Cloos, Jacqueline

N1 - Funding Information: This study was supported by a grant (KWF-IN-2006-22) from the Dutch Cancer Society.

PY - 2008/1

Y1 - 2008/1

N2 - Genetic variations in the polymorphic tandem repeat sequence of the enhancer region of the thymidylate synthase promoter (TSER), as well as in methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, influence methotrexate sensitivity. We studied these polymorphisms in children with acute lymphoblastic leukaemia (ALL) and in subjects without malignancy in Indonesia and Holland. The frequencies of TT and CT genotypes were two-fold higher in Dutch children. The TSER 3R/3R repeat was three-fold more frequent in the Indonesian children, while the 2R/2R repeat was only 1% compared to 21% in the Dutch children. No differences of these polymorphisms were found between ALL cells and normal blood cells, indicating an ethnic rather than leukemic origin. These results may have implications for treatment of Indonesian children with ALL.

AB - Genetic variations in the polymorphic tandem repeat sequence of the enhancer region of the thymidylate synthase promoter (TSER), as well as in methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, influence methotrexate sensitivity. We studied these polymorphisms in children with acute lymphoblastic leukaemia (ALL) and in subjects without malignancy in Indonesia and Holland. The frequencies of TT and CT genotypes were two-fold higher in Dutch children. The TSER 3R/3R repeat was three-fold more frequent in the Indonesian children, while the 2R/2R repeat was only 1% compared to 21% in the Dutch children. No differences of these polymorphisms were found between ALL cells and normal blood cells, indicating an ethnic rather than leukemic origin. These results may have implications for treatment of Indonesian children with ALL.

KW - Acute lymphoblastoid leukemia

KW - Indonesia

KW - MTHFR C677T

KW - Methotrexate

KW - Paediatric patients

KW - TSER 2R/3R

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SN - 0145-2126

VL - 32

SP - 19

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JF - Leukemia Research

IS - 1

ER -

Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

Abstract

Keywords

UN SDGs

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