TY - JOUR
T1 - Metabolite profiling of justicia gendarussa herbal drug preparations
AU - Ratih, Gusti Ayu Made
AU - Imawati, Maria Fatmadewi
AU - Purwanti, Diah Intan
AU - Nugroho, Rendra Rizki
AU - Wongso, Suwidji
AU - Prajogo, Bambang
AU - Indrayanto, Gunawan
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for theresearch, authorship, and/or publication of this article: This work “Penelitian Unggulan Fakultas SK Rektor No 886/UN3/2018” was supported by Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia.
Publisher Copyright:
© The Author(s) 2019.
PY - 2019/6
Y1 - 2019/6
N2 - Metabolite profiling can be applied as a reliable quality control (QC) tool for herbal drug preparations, especially if the specifications of the quality markers have not yet been determined. Some herbal drug preparations of Justicia gendarussa (JG), ie acidified dried crude drugs, ethanol extracts, laboratory-made granule preparations, and industrial-scale produced granules, could be clearly differentiated by using a combination of ultra-performance liquid chromatography ultra-high-resolution quadrupole-time-of-flight-mass spectrometry and multivariate analysis; unfortunately, attenuated total reflection-Fourier transform-infra-red spectroscopy could not be applied. The differences in the metabolite profiles were caused mostly by the variations in the concentrations of some fatty acid components. This work showed that classification analysis can be applied for reliable QC purposes of the J. gendarussa herbal drug preparations; the industrial-made granules of JG were located in the correct cluster of the score plot of the training set.
AB - Metabolite profiling can be applied as a reliable quality control (QC) tool for herbal drug preparations, especially if the specifications of the quality markers have not yet been determined. Some herbal drug preparations of Justicia gendarussa (JG), ie acidified dried crude drugs, ethanol extracts, laboratory-made granule preparations, and industrial-scale produced granules, could be clearly differentiated by using a combination of ultra-performance liquid chromatography ultra-high-resolution quadrupole-time-of-flight-mass spectrometry and multivariate analysis; unfortunately, attenuated total reflection-Fourier transform-infra-red spectroscopy could not be applied. The differences in the metabolite profiles were caused mostly by the variations in the concentrations of some fatty acid components. This work showed that classification analysis can be applied for reliable QC purposes of the J. gendarussa herbal drug preparations; the industrial-made granules of JG were located in the correct cluster of the score plot of the training set.
KW - Acanthaceae
KW - Fatty acid variations
KW - Gandarusa
KW - Justicia gendarussa
KW - Metabolite profiling
KW - Quality control
UR - http://www.scopus.com/inward/record.url?scp=85067404164&partnerID=8YFLogxK
U2 - 10.1177/1934578X19856252
DO - 10.1177/1934578X19856252
M3 - Article
AN - SCOPUS:85067404164
SN - 1934-578X
VL - 14
JO - Natural Product Communications
JF - Natural Product Communications
IS - 6
ER -