TY - JOUR
T1 - Metabolite Profiling of Different Parts of Syzygium cumini var. album and Physicochemical Testing of its Identical Compounds
AU - Andhiarto, Yanu
AU - Muslikh, Faisal Akhmal
AU - Suciati,
AU - Sukardiman,
N1 - Publisher Copyright:
© 2024 Phcogj.Com.
PY - 2024/11
Y1 - 2024/11
N2 - Indonesia is the second most biodiverse country in the world and is classified as a megadiverse country. Syzygium cumini is known to have various pharmacological activities, such as anti-inflammatory, antioxidant, antibacterial, antifungal, antidiarrheal, and others. This study aims to explore the metabolite profile of 70% ethanolic extract from the leaves and bark of Syzygium cumini var. album and analyze the physicochemical properties of its identical compounds. Phytochemical screening was conducted using commonly used methods, and metabolite profiling was carried out using UPLC-QToF-MS/MS. Pharmacological bioactivity and physicochemical properties of the identified compounds were analyzed using web tools such as Way2Drug, SwissADME, and ProTox II. The results showed that the ethanolic extract of Syzygium cumini var. album leaves contain 33 compounds, while the bark extract contains 26 compounds. Morin and alnusiin were identified in both samples. Based on PASS activity testing, morin exhibited Chlordecone reductase inhibitor activity and has potential for further development due to its favorable physicochemical properties and safety profile based on toxicity tests. This study demonstrates that the leaf and bark extracts of Syzygium cumini var. album contain morin and alnusiin, with morin showing potential as an effective and safe therapeutic agent as a Chlordecone reductase inhibitor.
AB - Indonesia is the second most biodiverse country in the world and is classified as a megadiverse country. Syzygium cumini is known to have various pharmacological activities, such as anti-inflammatory, antioxidant, antibacterial, antifungal, antidiarrheal, and others. This study aims to explore the metabolite profile of 70% ethanolic extract from the leaves and bark of Syzygium cumini var. album and analyze the physicochemical properties of its identical compounds. Phytochemical screening was conducted using commonly used methods, and metabolite profiling was carried out using UPLC-QToF-MS/MS. Pharmacological bioactivity and physicochemical properties of the identified compounds were analyzed using web tools such as Way2Drug, SwissADME, and ProTox II. The results showed that the ethanolic extract of Syzygium cumini var. album leaves contain 33 compounds, while the bark extract contains 26 compounds. Morin and alnusiin were identified in both samples. Based on PASS activity testing, morin exhibited Chlordecone reductase inhibitor activity and has potential for further development due to its favorable physicochemical properties and safety profile based on toxicity tests. This study demonstrates that the leaf and bark extracts of Syzygium cumini var. album contain morin and alnusiin, with morin showing potential as an effective and safe therapeutic agent as a Chlordecone reductase inhibitor.
KW - Chlordecone reductase inhibitor
KW - Syzygium cumini var. album
KW - biological activity
KW - physicochemistry
KW - toxicity analysis
UR - http://www.scopus.com/inward/record.url?scp=85213869138&partnerID=8YFLogxK
U2 - 10.5530/pj.2024.16.206
DO - 10.5530/pj.2024.16.206
M3 - Article
AN - SCOPUS:85213869138
SN - 0975-3575
VL - 16
SP - 1272
EP - 1280
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 6
ER -