TY - JOUR
T1 - Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19
AU - Wungu, Citrawati Dyah Kencono
AU - Khaerunnisa, Siti
AU - Putri, Eka Arum Cahyaning
AU - Hidayati, Hanik Badriyah
AU - Qurnianingsih, Ema
AU - Lukitasari, Lina
AU - Humairah, Ira
AU - Soetjipto,
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/4
Y1 - 2021/4
N2 - Objectives: Previous observational studies have suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients. Methods: Several cardiac markers were analysed in this meta-analysis. RevMan 5.4 was used to provide pooled estimates for standardised mean difference (SMD) with 95% confidence intervals. Results: Twenty-nine clinical studies were included in this meta-analysis. Significantly higher CK-MB (0.64, 95% CI = 0.19–1.09), PCT (0.47, 95% CI = 0.26−0.68), NT-proBNP (1.90, 95% CI = 1.63–2.17), BNP (1.86, 95% CI = 1.63−2.09), and D-dimer (1.30, 95% CI = 0.91−1.69) were found in severe compared with non-severe COVID-19. Significantly higher CK-MB (3.84, 95% CI = 0.62−7.05), PCT (1.49, 95% CI = 0.86−2.13), NT-proBNP (4.66, 95% CI = 2.42−6.91), BNP (1.96, 95% CI = 0.78−3.14), troponin (1.64 (95% CI = 0.83−2.45), and D-dimer (2.72, 95% CI = 2.14−3.29) were found in those who died from compared with survivors of COVID-19. Conclusions: High CK-MB, PCT, NT-proBNP, BNP, and D-dimer could be predictive markers for severity of COVID-19, while high CK-MB, PCT, NT-proBNP, BNP, troponin, and D-dimer could be predictive markers for survival of COVID-19 patients.
AB - Objectives: Previous observational studies have suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients. Methods: Several cardiac markers were analysed in this meta-analysis. RevMan 5.4 was used to provide pooled estimates for standardised mean difference (SMD) with 95% confidence intervals. Results: Twenty-nine clinical studies were included in this meta-analysis. Significantly higher CK-MB (0.64, 95% CI = 0.19–1.09), PCT (0.47, 95% CI = 0.26−0.68), NT-proBNP (1.90, 95% CI = 1.63–2.17), BNP (1.86, 95% CI = 1.63−2.09), and D-dimer (1.30, 95% CI = 0.91−1.69) were found in severe compared with non-severe COVID-19. Significantly higher CK-MB (3.84, 95% CI = 0.62−7.05), PCT (1.49, 95% CI = 0.86−2.13), NT-proBNP (4.66, 95% CI = 2.42−6.91), BNP (1.96, 95% CI = 0.78−3.14), troponin (1.64 (95% CI = 0.83−2.45), and D-dimer (2.72, 95% CI = 2.14−3.29) were found in those who died from compared with survivors of COVID-19. Conclusions: High CK-MB, PCT, NT-proBNP, BNP, and D-dimer could be predictive markers for severity of COVID-19, while high CK-MB, PCT, NT-proBNP, BNP, troponin, and D-dimer could be predictive markers for survival of COVID-19 patients.
KW - COVID-19
KW - Cardiac marker
KW - Mortality
KW - Severity
UR - http://www.scopus.com/inward/record.url?scp=85102902253&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2021.03.008
DO - 10.1016/j.ijid.2021.03.008
M3 - Article
C2 - 33711519
AN - SCOPUS:85102902253
SN - 1201-9712
VL - 105
SP - 551
EP - 559
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -