Melimoluccanin, A new isoprenylated quinolone alkaloid from the leaves of Melicope moluccana T.G. Hartley

Tjitjik Srie Tjahjandarie, Ratih Dewi Saputri, Ryan Ayub Wahjoedi, Mulyadi Tanjung

Research output: Contribution to journalConference articlepeer-review

Abstract

A new quinolone alkaloid, melimoluccanin (1) along with two known alkaloids, leptanoine C (2) and 7-O-isoprenyl-γ-fagarin (3) were isolated from the leaves of Melicope moluccana T.G. Hartley. Structures all of compounds were elucidated using spectroscopic methods such as UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1-3 were evaluated for their cytotoxicity against P-388 cells and for antimalaria activity using giemsa methods. The cytotoxic data of compounds 1-3 showed IC50 of 0.63; 5.85 and 2.09 μg/mL, respectively. The antiplasmodial activity of compound 1-3 showed IC50 value of 4.28; 2,28 and 0.18 μg/mL, respectively. Based on the data, it can be concluded that compound 1 has high activity against P-388 cells and compound 3 is potential as antimalaria.

Original languageEnglish
Article number012042
JournalJournal of Physics: Conference Series
Volume1095
Issue number1
DOIs
Publication statusPublished - 10 Oct 2018
Event6th International Conference of the Indonesian Chemical Society, ICIC 2017 - Palembang, South Sumatra, Indonesia
Duration: 17 Oct 201718 Oct 2017

Keywords

  • antimalaria
  • Melicope moluccana
  • Melimoluccanin

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