TY - JOUR
T1 - Melimoluccanin, A new isoprenylated quinolone alkaloid from the leaves of Melicope moluccana T.G. Hartley
AU - Srie Tjahjandarie, Tjitjik
AU - Dewi Saputri, Ratih
AU - Ayub Wahjoedi, Ryan
AU - Tanjung, Mulyadi
N1 - Funding Information:
This research was supported by Directorate of Higher Education, Ministry of National Education, Republic of Indonesia (Penelitian Hibah Mandat, Universitas Airlangga, 2017).
Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2018/10/10
Y1 - 2018/10/10
N2 - A new quinolone alkaloid, melimoluccanin (1) along with two known alkaloids, leptanoine C (2) and 7-O-isoprenyl-γ-fagarin (3) were isolated from the leaves of Melicope moluccana T.G. Hartley. Structures all of compounds were elucidated using spectroscopic methods such as UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1-3 were evaluated for their cytotoxicity against P-388 cells and for antimalaria activity using giemsa methods. The cytotoxic data of compounds 1-3 showed IC50 of 0.63; 5.85 and 2.09 μg/mL, respectively. The antiplasmodial activity of compound 1-3 showed IC50 value of 4.28; 2,28 and 0.18 μg/mL, respectively. Based on the data, it can be concluded that compound 1 has high activity against P-388 cells and compound 3 is potential as antimalaria.
AB - A new quinolone alkaloid, melimoluccanin (1) along with two known alkaloids, leptanoine C (2) and 7-O-isoprenyl-γ-fagarin (3) were isolated from the leaves of Melicope moluccana T.G. Hartley. Structures all of compounds were elucidated using spectroscopic methods such as UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1-3 were evaluated for their cytotoxicity against P-388 cells and for antimalaria activity using giemsa methods. The cytotoxic data of compounds 1-3 showed IC50 of 0.63; 5.85 and 2.09 μg/mL, respectively. The antiplasmodial activity of compound 1-3 showed IC50 value of 4.28; 2,28 and 0.18 μg/mL, respectively. Based on the data, it can be concluded that compound 1 has high activity against P-388 cells and compound 3 is potential as antimalaria.
KW - antimalaria
KW - Melicope moluccana
KW - Melimoluccanin
UR - http://www.scopus.com/inward/record.url?scp=85056471249&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/1095/1/012042
DO - 10.1088/1742-6596/1095/1/012042
M3 - Conference article
AN - SCOPUS:85056471249
SN - 1742-6588
VL - 1095
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 1
M1 - 012042
T2 - 6th International Conference of the Indonesian Chemical Society, ICIC 2017
Y2 - 17 October 2017 through 18 October 2017
ER -