Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia

Adil Astulla; Yusuke Hirasawa; Abdul Rahman; Idha Kusumawati; Wiwied Ekasari; Aty Widyawaruyanti; Noor Cholies Zaini; Hiroshi Morita

doi:10.1177/1934578x1100600304

Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia

Adil Astulla, Yusuke Hirasawa, Abdul Rahman, Idha Kusumawati, Wiwied Ekasari, Aty Widyawaruyanti, Noor Cholies Zaini, Hiroshi Morita

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC₅₀ of 6.1 and 7.3 μg/mL, respectively.

Original language	English
Pages (from-to)	323-326
Number of pages	4
Journal	Natural Product Communications
Volume	6
Issue number	3
DOIs	https://doi.org/10.1177/1934578x1100600304
Publication status	Published - Mar 2011

Keywords

Acyclic diterpene
Antimalarial activity
Aphanamixis grandifolia
Melidianolic acids A and B
Plasmodium falciparum 3D7

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10.1177/1934578x1100600304

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title = "Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia",

abstract = "Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 μg/mL, respectively.",

keywords = "Acyclic diterpene, Antimalarial activity, Aphanamixis grandifolia, Melidianolic acids A and B, Plasmodium falciparum 3D7",

author = "Adil Astulla and Yusuke Hirasawa and Abdul Rahman and Idha Kusumawati and Wiwied Ekasari and Aty Widyawaruyanti and Zaini, {Noor Cholies} and Hiroshi Morita",

year = "2011",

month = mar,

doi = "10.1177/1934578x1100600304",

language = "English",

volume = "6",

pages = "323--326",

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T1 - Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia

AU - Astulla, Adil

AU - Hirasawa, Yusuke

AU - Rahman, Abdul

AU - Kusumawati, Idha

AU - Ekasari, Wiwied

AU - Widyawaruyanti, Aty

AU - Zaini, Noor Cholies

AU - Morita, Hiroshi

PY - 2011/3

Y1 - 2011/3

N2 - Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 μg/mL, respectively.

AB - Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 μg/mL, respectively.

KW - Acyclic diterpene

KW - Antimalarial activity

KW - Aphanamixis grandifolia

KW - Melidianolic acids A and B

KW - Plasmodium falciparum 3D7

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DO - 10.1177/1934578x1100600304

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AN - SCOPUS:79955771493

SN - 1934-578X

VL - 6

SP - 323

EP - 326

JO - Natural Product Communications

JF - Natural Product Communications

IS - 3

ER -

Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia

Abstract

Keywords

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