TY - JOUR
T1 - Medicinal plants of Southeast Asia with anti-α-glucosidase activity as potential source for Type-2 diabetes mellitus treatment
AU - Benjamin, Mohammad Amil Zulhilmi
AU - Mohd Mokhtar, Ruzaidi Azli
AU - Iqbal, Mohammad
AU - Abdullah, Azmahani
AU - Azizah, Roro
AU - Sulistyorini, Lilis
AU - Mahfudh, Nurkhasanah
AU - Zakaria, Zainul Amiruddin
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/8/10
Y1 - 2024/8/10
N2 - Ethnopharmacological relevance: Diabetes mellitus, a widespread chronic illness, affects millions worldwide, and its incidence is increasing alarmingly, especially in developing nations. Current pharmacological treatments can be costly and have undesirable side effects. To address this, medicinal plants with antidiabetic effects, particularly targeting α-glucosidase for controlling hyperglycaemia in type-2 diabetes mellitus (T2DM), hold promise for drug development with reduced toxicity and adverse reactions. Aim of this review: This review aims to succinctly collect information about medicinal plant extracts that exhibit antidiabetic potential through α-glucosidase inhibition using acarbose as a standard reference in Southeast Asia. The characteristics of this inhibition are based on in vitro studies. Materials and methods: Relevant information on medicinal plants in Southeast Asia, along with α-glucosidase inhibition studies using acarbose as a positive control, was gathered from various scientific databases, including Scopus, PubMed, Web of Science, and Google Scholar. Results: About 46 papers were found from specific counties in Southeast Asia demonstrated notable α-glucosidase inhibitory potential of their medicinal plants, with several plant extracts showcasing activity comparable to or surpassing that of acarbose. Notably, 19 active constituents were identified for their α-glucosidase inhibitory effects. Conclusions: The findings underscore the antidiabetic potential of the tested medicinal plant extracts, indicating their promise as alternative treatments for T2DM. This review can aid in the development of potent therapeutic medicines with increased effectiveness and safety for the treatment of T2DM.
AB - Ethnopharmacological relevance: Diabetes mellitus, a widespread chronic illness, affects millions worldwide, and its incidence is increasing alarmingly, especially in developing nations. Current pharmacological treatments can be costly and have undesirable side effects. To address this, medicinal plants with antidiabetic effects, particularly targeting α-glucosidase for controlling hyperglycaemia in type-2 diabetes mellitus (T2DM), hold promise for drug development with reduced toxicity and adverse reactions. Aim of this review: This review aims to succinctly collect information about medicinal plant extracts that exhibit antidiabetic potential through α-glucosidase inhibition using acarbose as a standard reference in Southeast Asia. The characteristics of this inhibition are based on in vitro studies. Materials and methods: Relevant information on medicinal plants in Southeast Asia, along with α-glucosidase inhibition studies using acarbose as a positive control, was gathered from various scientific databases, including Scopus, PubMed, Web of Science, and Google Scholar. Results: About 46 papers were found from specific counties in Southeast Asia demonstrated notable α-glucosidase inhibitory potential of their medicinal plants, with several plant extracts showcasing activity comparable to or surpassing that of acarbose. Notably, 19 active constituents were identified for their α-glucosidase inhibitory effects. Conclusions: The findings underscore the antidiabetic potential of the tested medicinal plant extracts, indicating their promise as alternative treatments for T2DM. This review can aid in the development of potent therapeutic medicines with increased effectiveness and safety for the treatment of T2DM.
KW - Acarbose
KW - Active constituents
KW - Medicinal plants
KW - Southeast asia
KW - Type-2 diabetes mellitus
KW - α-Glucosidase inhibition
UR - http://www.scopus.com/inward/record.url?scp=85191321622&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2024.118239
DO - 10.1016/j.jep.2024.118239
M3 - Review article
AN - SCOPUS:85191321622
SN - 0378-8741
VL - 330
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
M1 - 118239
ER -