Diagnosis of ambiguous genitalia in newborns is difficult to determine, most cases in young children appear when they begin to reach puberty. We report a longitudinal case study of a child grown as a 12-year-old boy with ambiguous genitalia from a medical and psychosexual perspective. Based on the patient's medical condition, treatment adherence was excellent. This observation will continue to be monitored and assessed by educating patients to undergo monthly checkups at the pediatric endocrinology polyclinic. From the growth aspect, the patient has experienced weight loss but has not yet reached normal nutritional status. Based on the psychosexual side of the patient, there was light depression and low anxiety towards the conclusion of the patient's observation. The patient's intelligence, however, is comparable to that of children his age. After the examination, the patient was also able to adapt to life as a woman. Therefore, gender dysphoria is no longer present. In total, it was found that there was growth and development of female secondary sex characteristics in patients after consuming hormonal substitution therapy. The patient also saw an increase in the patient's self-confidence after experiencing a sex change compared to the initial observation. The patient has also legally authorized the alteration of the patient's gender.

Original languageEnglish
Pages (from-to)1519-1529
Number of pages11
JournalJournal of Medicinal and Pharmaceutical Chemistry Research
Issue number10
Publication statusPublished - Oct 2024


  • 46,XX
  • ambiguous genitalia
  • disorders of sex development (DSD)
  • psychosexual


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